The long non-coding RNAs associating with other molecules can coordinate several
physiological processes and their dysfunction can impact diverse human diseases. To date …

Metastasis is one of the most challenging issues in cancer patient management, and
effective therapies to specifically target disease progression are missing, emphasizing the …

Cancer progression to metastatic stages is still unmanageable and the promise of effective
anti-metastatic therapy remains largely unmet, emphasizing the need to develop novel …

Identification of driver genes contributes to the understanding of cancer etiology and is
imperative for the development of individualized therapies. Gene amplification is a major …

Elevation of the DNA-unwinding helicase RECQL4, which participates in various DNA repair
pathways, has been suggested to contribute to the pathogenicity of various human cancers …

Impaired DNA repair drives mutagenicity, which increases neoantigen load and
immunogenicity. We investigated the expression of proteins involved in the DNA damage …

DNA damage constantly threatens genome integrity, and DNA repair deficiency is
associated with increased cancer risk. An intuitive and widely accepted explanation for this …

Circulating tumor DNA (ctDNA) in peripheral blood has been used to predict prognosis and
therapeutic response for triple-negative breast cancer (TNBC) patients. However, previous …

Human RecQ helicases that share homology with E. coli RecQ helicase play critical roles in
diverse biological activities such as DNA replication, transcription, recombination and repair …

RECQL4 is a member of the evolutionarily conserved RecQ family of 3'to 5'DNA helicases.
RECQL4 is critical for maintaining genomic stability through its functions in DNA repair …