lncRNAfunc: a knowledgebase of lncRNA function in human cancer
The long non-coding RNAs associating with other molecules can coordinate several
physiological processes and their dysfunction can impact diverse human diseases. To date …
physiological processes and their dysfunction can impact diverse human diseases. To date …
Emerging functional markers for cancer stem cell-based therapies: Understanding signaling networks for targeting metastasis
S Marquardt, M Solanki, A Spitschak, J Vera… - Seminars in cancer …, 2018 - Elsevier
Metastasis is one of the most challenging issues in cancer patient management, and
effective therapies to specifically target disease progression are missing, emphasizing the …
effective therapies to specifically target disease progression are missing, emphasizing the …
Advances in cancer stem cell targeting: How to strike the evil at its root
BM Pützer, M Solanki, O Herchenröder - Advanced drug delivery reviews, 2017 - Elsevier
Cancer progression to metastatic stages is still unmanageable and the promise of effective
anti-metastatic therapy remains largely unmet, emphasizing the need to develop novel …
anti-metastatic therapy remains largely unmet, emphasizing the need to develop novel …
Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors
K Ohshima, K Hatakeyama, T Nagashima… - Scientific reports, 2017 - nature.com
Identification of driver genes contributes to the understanding of cancer etiology and is
imperative for the development of individualized therapies. Gene amplification is a major …
imperative for the development of individualized therapies. Gene amplification is a major …
Human helicase RECQL4 drives cisplatin resistance in gastric cancer by activating an AKT–YB1–MDR1 signaling pathway
D Mo, H Fang, K Niu, J Liu, M Wu, S Li, T Zhu… - Cancer Research, 2016 - AACR
Elevation of the DNA-unwinding helicase RECQL4, which participates in various DNA repair
pathways, has been suggested to contribute to the pathogenicity of various human cancers …
pathways, has been suggested to contribute to the pathogenicity of various human cancers …
Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers
AR Green, MA Aleskandarany, R Ali, EG Hodgson… - Cancer immunology …, 2017 - AACR
Impaired DNA repair drives mutagenicity, which increases neoantigen load and
immunogenicity. We investigated the expression of proteins involved in the DNA damage …
immunogenicity. We investigated the expression of proteins involved in the DNA damage …
Human variation in DNA repair, immune function, and cancer risk
A Cheong, ZD Nagel - Frontiers in immunology, 2022 - frontiersin.org
DNA damage constantly threatens genome integrity, and DNA repair deficiency is
associated with increased cancer risk. An intuitive and widely accepted explanation for this …
associated with increased cancer risk. An intuitive and widely accepted explanation for this …
Personalized ctDNA micro-panels can monitor and predict clinical outcomes for patients with triple-negative breast cancer
Circulating tumor DNA (ctDNA) in peripheral blood has been used to predict prognosis and
therapeutic response for triple-negative breast cancer (TNBC) patients. However, previous …
therapeutic response for triple-negative breast cancer (TNBC) patients. However, previous …
Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells
D Mo, Y Zhao, AS Balajee - Cancer letters, 2018 - Elsevier
Human RecQ helicases that share homology with E. coli RecQ helicase play critical roles in
diverse biological activities such as DNA replication, transcription, recombination and repair …
diverse biological activities such as DNA replication, transcription, recombination and repair …
Role and regulation of the RECQL4 family during genomic integrity maintenance
TT Luong, KA Bernstein - Genes, 2021 - mdpi.com
RECQL4 is a member of the evolutionarily conserved RecQ family of 3'to 5'DNA helicases.
RECQL4 is critical for maintaining genomic stability through its functions in DNA repair …
RECQL4 is critical for maintaining genomic stability through its functions in DNA repair …