During the recent past years, tremendous efforts have been made to establish
enantioselective routes for the preparation of enantiomerically pure compounds due to their …

The free energy landscape concept that describes enzymes as an ensemble of differently
populated conformational sub-states in dynamic equilibrium is key for evaluating enzyme …

In this Minireview, the importance and implementation of green chemistry practices in the
pharmaceutical industry are illustrated. With notable examples, some of the most important …

Herein we review recent advances in the asymmetric reduction of ketones by biocatalysts.
Included are discussions on recent developments in methodologies to control …

Eupergit® C is a carrier consisting of macroporous beads for immobilizing enzymes of
industrial potential for the production of fine chemicals and pharmaceuticals. Various …

Chiral catalyst development is a key to asymmetric catalysis research. The enantioselectivity
of a chiral catalyst relies on its ability to distinguish the prochiral centres or faces of …

Alcohol dehydrogenases (ADHs) have become important catalysts for stereoselective
oxidation and reduction reactions of alcohols, aldehydes and ketones. The aim of this …

Dehydrogenases which depend on nicotinamide coenzymes are of increasing interest for
the preparation of chiral compounds, either by reduction of a prochiral precursor or by …

The computational study of enantioselective reactions is a challenging task that requires
high accuracy, as very small energy differences have to be reproduced. Quantum chemical …

Diisopinocampheylchloroborane, readily prepared in both enantiomers in high chemical
and optical purities (99% ee) via hydroboration followed by treatment with dry hydrogen …