Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?

A Santoro, E Bientinesi, D Monti - Ageing research reviews, 2021 - Elsevier
During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …

[HTML][HTML] Metabolism of vascular smooth muscle cells in vascular diseases

J Shi, Y Yang, A Cheng, G Xu… - American Journal of …, 2020 - journals.physiology.org
Vascular smooth muscle cells (VSMCs) are the fundamental component of the medial layer
of arteries and are essential for arterial physiology and pathology. It is becoming …

[HTML][HTML] Diretrizes brasileiras de hipertensão arterial–2020

WKS Barroso, CIS Rodrigues, LA Bortolotto… - Arquivos brasileiros de …, 2021 - SciELO Brasil
A hipertensão arterial (HA) é uma doença crônica não transmissível (DCNT) definida por
níveis pressóricos, em que os benefícios do tratamento (não medicamentoso e/ou …

Brazilian guidelines of hypertension–2020

WKS Barroso, CIS Rodrigues, LA Bortolotto… - Arquivos brasileiros de …, 2021 - SciELO Brasil
SciELO - Brasil - Diretrizes Brasileiras de Hipertensão Arterial – 2020 Diretrizes Brasileiras de
Hipertensão Arterial – 2020 Acessibilidade / Reportar erro Brasil Lista alfabética de periódicos …

miR-21 and miR-146a: the microRNAs of inflammaging and age-related diseases

F Olivieri, F Prattichizzo, A Giuliani… - Ageing research …, 2021 - Elsevier
The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …

Deep neural network-estimated electrocardiographic age as a mortality predictor

EM Lima, AH Ribeiro, GMM Paixão, MH Ribeiro… - Nature …, 2021 - nature.com
The electrocardiogram (ECG) is the most commonly used exam for the evaluation of
cardiovascular diseases. Here we propose that the age predicted by artificial intelligence …

Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

SK Ahuja, MS Manoharan, GC Lee… - Nature …, 2023 - nature.com
Some people remain healthier throughout life than others but the underlying reasons are
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …

[HTML][HTML] Major depression and the biological hallmarks of aging

EC Lorenzo, GA Kuchel, CL Kuo, TE Moffitt… - Ageing research …, 2023 - Elsevier
Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …

Progression of Early Subclinical Atherosclerosis (PESA) Study: JACC Focus Seminar 7/8

B Ibanez, A Fernández-Ortiz, L Fernández-Friera… - Journal of the American …, 2021 - jacc.org
Atherosclerosis starts early in life and progresses silently for decades. Considering
atherosclerosis as a “systemic disease” invites the use of noninvasive methodologies to …

Assessing hemodynamics from the photoplethysmogram to gain insights into vascular age: a review from VascAgeNet

PH Charlton, B Paliakaitė, K Pilt… - American Journal …, 2022 - journals.physiology.org
The photoplethysmogram (PPG) signal is widely measured by clinical and consumer
devices, and it is emerging as a potential tool for assessing vascular age. The shape and …