Enteroviruses are believed to trigger or accelerate islet autoimmunity in genetically
susceptible individuals, thereby resulting in loss of functional insulin-producing β-cells and …

Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

We present an integrated analysis of the clinical measurements, immune cells, and plasma
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …

Pyroptosis is a newly discovered programmed cell death with inflammasome formation.
Pattern recognition receptors that identify repetitive motifs of prospective pathogens such as …

In the past half century, humanity has experienced two devastating pandemics; the HIV-1
pandemic and the recent pandemic caused by SARS-CoV-2. Both emerged as zoonotic …

Background: CD38+ NK (CD3− CD16+ CD38+ CD56+) cells were increased in rheumatoid
arthritis (RA), which suppressed Treg cell differentiation. This study explored how CD38+ NK …

Although highly effective at durably suppressing plasma HIV-1 viremia, combination
antiretroviral therapy (ART) treatment regimens do not eradicate the virus, which persists in …

It has been suggested that the persistence of coxsackieviruses-B (CV-B) in pancreatic beta
cells plays a role in the pathogenesis of type 1 diabetes (T1D). Yet, immunological effectors …

Enteroviruses, especially group B coxsackieviruses (CV-B), have been associated with the
development of chronic diseases such as type 1 diabetes (T1D). The pathological …

IL-15 is a key regulator of NK cell maintenance and proliferation and synergizes with other
myeloid cell–derived cytokines to enhance NK cell effector function. At low concentrations …