The potential of human induced pluripotent stem cells (iPSCs) to self-renew indefinitely and
to differentiate virtually into any cell type in unlimited quantities makes them attractive for in …

DNA mutations as a consequence of errors during DNA damage repair, replication, or
mitosis are the substrate for evolution. In multicellular organisms, mutations can occur in the …

Somatic mosaicism in the human brain may alter function of individual neurons. We
analyzed genomes of single cells from the forebrains of three human fetuses (15 to 21 …

Somatic mutations have been studied extensively in the context of cancer. Recent studies
have demonstrated that high-throughput sequencing data can be used to detect somatic …

Human aging is associated with a decline in skeletal muscle (SkM) function and a reduction
in the number and activity of satellite cells (SCs), the resident stem cells. To study the …

Somatic evolution of cells within the body is well known to lead to cancers. However, spread
of somatic mutations within a tissue over time may also contribute to the pathogenesis of non …

High-accuracy next-generation DNA sequencing promises a paradigm shift in early cancer
detection by enabling the identification of mutant cancer molecules in minimally invasive …

Background The lifelong accumulation of somatic mutations underlies age-related
phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in …

Genetic integrity of induced pluripotent stem cells (iPSCs) is essential for their validity as
disease models and for potential therapeutic use. We describe the comprehensive analysis …

Background—The Global Asthma Network (GAN) Phase I is surveying school pupils in high-
income and low-or middle-income countries using the International Study of Asthma and …