Pharmaceutical solid dosage forms (tablets or capsules) are the predominant form to
administer active pharmaceutical ingredients (APIs) to the patient. Tablets are typically …

Disintegrant is one of the most important components in a typical tablet dosage form. It is
responsible for ensuring the break-up of the tablet matrix upon ingestion. Disintegrants act …

Fused deposition modelling (FDM) 3D printing has shown the most immediate potential for
on-demand dose personalisation to suit particular patient's needs. However, FDM 3D …

Context: Tablet disintegration is an important factor for drug release and can be modified
with excipients called tablet disintegrants. Tablet disintegrants act via different mechanisms …

Disintegration is the de-aggregation of particles within tablets upon exposure to aqueous
fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental …

The design and manufacture of tablets is a challenging process due to the complex
interrelationships between raw material properties, the manufacturing settings and the tablet …

The main purpose of this study was to develop gastroretentive tablets with floating and
swelling properties for once-daily administration of pregabalin. The non-effervescent floating …

Investigation of the effect of disintegrants on the disintegration time and hardness of rapidly
disintegrating tablets (RDTs) was carried out using a quality by design (QbD) paradigm …

Functional-related characteristics (FRCs) are properties of excipients that can potentially
influence one or more functions of that excipient in the final product. Knowledge of FRCs is …

Particle swelling is a crucial component in the disintegration of a pharmaceutical tablet. The
swelling of particles in a tablet creates stress inside the tablet and thereby pushes apart …