Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

We review approaches aimed at deciphering the physical mechanisms responsible for viral
structure and assembly. We discuss the basic principles of condensed matter physics …

Viral capsids are often regarded as inert structural units, but in actuality they display
fascinating dynamics during different stages of their life cycle. With the advent of single …

Now routine is the ability to investigate soluble and membrane protein complexes in the gas
phase of a mass spectrometer while preserving folded structure and ligand-binding …

Native mass spectrometry (MS) is aimed at preserving and determining the native structure,
composition, and stoichiometry of biomolecules and their complexes from solution after they …

The classical complement pathway contributes to the natural immune defense against
pathogens and tumors. IgG antibodies can assemble at the cell surface into hexamers via …

Accurate mass analysis can provide useful information on the stoichiometry and composition
of protein-based particles, such as virus-like assemblies. For applications in nanotechnology …

Progress in structural biology research has led to a high demand for powerful and yet
complementary analytical tools for structural characterization of proteins and protein …

Over the past two decades, mass spectrometry (MS) of protein complexes from their native
state has made inroads into structural biology. To coincide with the 20 th anniversary of …