Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

Autophagosome biogenesis involves de novo formation of a membrane that elongates to
sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an …

Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …

Autophagy is a conserved intracellular pathway that delivers cytoplasmic contents to
lysosomes for degradation via double-membrane autophagosomes. Autophagy substrates …

Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …

Autophagy has burgeoned rapidly as a field of study because of its evolutionary
conservation, the diversity of intracellular cargoes degraded and recycled by this machinery …

Autophagosome formation requires sequential translocation of autophagy-specific proteins
to membranes enriched in PI3P and connected to the ER. Preceding this, the earliest …

Intracellular membrane fusion is mediated in most cases by membrane-bridging complexes
of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) …

Autophagy represents an intracellular degradation process which is involved in both cellular
homeostasis and disease settings. In the last two decades, the molecular machinery …

Autophagy is an enigmatic cellular process in which double-membrane compartments,
called “autophagosomes, form de novo adjacent to the endoplasmic reticulum (ER) and …