Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer's disease: understanding the therapeutics strategies
Synapses are formed by interneuronal connections that permit a neuronal cell to pass an
electrical or chemical signal to another cell. This passage usually gets damaged or lost in …
electrical or chemical signal to another cell. This passage usually gets damaged or lost in …
What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer's disease, about the therapeutic strategies in Alzheimer's research
M Salkovic-Petrisic, A Knezovic, S Hoyer… - Journal of neural …, 2013 - Springer
Experimental models that faithfully mimic the developmental pathology of sporadic
Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic …
Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic …
Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type
The objective of the present study was to assess the neuroprotective role of rutin (vitamin P)
and delineate the mechanism of action. Recent evidence indicates that rutin exhibits …
and delineate the mechanism of action. Recent evidence indicates that rutin exhibits …
Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease
Type 2 diabetes (T2D) is one of the major risk factors associated with Alzheimer's disease
(AD). Recent studies have found similarities in molecular mechanisms that underlie the …
(AD). Recent studies have found similarities in molecular mechanisms that underlie the …
Natural compounds as beneficial antioxidant agents in neurodegenerative disorders: A focus on Alzheimer's disease
A Amato, S Terzo, F Mulè - Antioxidants, 2019 - mdpi.com
The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that
dietary interventions represent helpful tools for preventing NDs. In particular, diets enriched …
dietary interventions represent helpful tools for preventing NDs. In particular, diets enriched …
Streptozotocin intracerebroventricular-induced neurotoxicity and brain insulin resistance: a therapeutic intervention for treatment of sporadic Alzheimer's disease (sAD …
Alzheimer's disease (AD) is a neurodegenerative disorder that is remarkably characterized
by pathological hallmarks which include amyloid plaques, neurofibrillary tangles, neuronal …
by pathological hallmarks which include amyloid plaques, neurofibrillary tangles, neuronal …
Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease
J Kosaraju, V Murthy, RB Khatwal… - Journal of Pharmacy …, 2013 - academic.oup.com
Objectives Adults who develop type 2 diabetes (T2D) at later stages are at a higher risk of
developing Alzheimer's disease (AD). Pharmacological agents such as dipeptidyl peptidase …
developing Alzheimer's disease (AD). Pharmacological agents such as dipeptidyl peptidase …
Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: A dual-target drug for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is characterized by amyloid β (Aβ) peptide aggregation and
cholinergic neurodegeneration. Therefore, in this paper, we examined silibinin, a flavonoid …
cholinergic neurodegeneration. Therefore, in this paper, we examined silibinin, a flavonoid …
Hesperidin and silibinin ameliorate aluminum-induced neurotoxicity: modulation of antioxidants and inflammatory cytokines level in mice hippocampus
Mounting evidence suggests that long-term aluminum exposure results in severe toxic
effects, including neurobehavioral and neurochemical anomalies. The present study was …
effects, including neurobehavioral and neurochemical anomalies. The present study was …
Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment …
Recent attention is given to the influence of dietary supplementation on health and mental
well-being. Oxidative stress is associated with many diseases including neurodegenerative …
well-being. Oxidative stress is associated with many diseases including neurodegenerative …