Astrocyte energy and neurotransmitter metabolism in Alzheimer's disease: integration of the glutamate/GABA-glutamine cycle

JV Andersen, A Schousboe, A Verkhratsky - Progress in neurobiology, 2022 - Elsevier
Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

The neurovasculome: key roles in brain health and cognitive impairment: a scientific statement from the American Heart Association/American Stroke Association

C Iadecola, EE Smith, J Anrather, C Gu, A Mishra… - Stroke, 2023 - Am Heart Assoc
Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …

Infiltrating CD8+ T cells exacerbate Alzheimer's disease pathology in a 3D human neuroimmune axis model

M Jorfi, J Park, CK Hall, CCJ Lin, M Chen… - Nature …, 2023 - nature.com
Brain infiltration of peripheral immune cells and their interactions with brain-resident cells
may contribute to Alzheimer's disease (AD) pathology. To examine these interactions, in the …

[HTML][HTML] Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity

MB Victor, N Leary, X Luna, HS Meharena… - Cell Stem Cell, 2022 - cell.com
Summary Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for
developing sporadic Alzheimer's disease. How the interaction of APOE4 microglia with …

Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model

Z Liu, J Chao, C Wang, G Sun, D Roeth, W Liu, X Chen… - Cell reports, 2023 - cell.com
The C allele of rs11136000 variant in the clusterin (CLU) gene represents the third strongest
known genetic risk factor for late-onset Alzheimer's disease. However, whether this single …

Blood–brain barrier endothelial cells in neurodegenerative diseases: signals from the “barrier”

Y Yuan, J Sun, Q Dong, M Cui - Frontiers in Neuroscience, 2023 - frontiersin.org
As blood–brain barrier (BBB) disruption emerges as a common problem in the early stages
of neurodegenerative diseases, the crucial roles of barrier-type brain endothelial cells …

A survey on continual semantic segmentation: Theory, challenge, method and application

B Yuan, D Zhao - IEEE Transactions on Pattern Analysis and …, 2024 - ieeexplore.ieee.org
Continual learning, also known as incremental learning or life-long learning, stands at the
forefront of deep learning and AI systems. It breaks through the obstacle of one-way training …

Hydroxytyrosol–Donepezil Hybrids Play a Protective Role in an In Vitro Induced Alzheimer's Disease Model and in Neuronal Differentiated Human SH-SY5Y …

J Maiuolo, P Costanzo, M Masullo, A D'Errico… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative pathology among
progressive dementias, and it is characterized by the accumulation in the brain of …

Inhibitory effects of Jasminum grandiflorum L. essential oil on lipopolysaccharide-induced microglia activation-integrated characteristic analysis of volatile compounds …

J Lu, X Zeng, Y Feng, S Li, Y Wang, Y Liu… - Frontiers in …, 2023 - frontiersin.org
Neuroinflammation is considered to have a prominent role in the pathogenesis of
Alzheimer's disease (AD). Microglia are the resident macrophages of the central nervous …

Advanced in vitro models: microglia in action

B Cakir, FR Kiral, IH Park - Neuron, 2022 - cell.com
In the central nervous system (CNS), microglia carry out multiple tasks related to brain
development, maintenance of brain homeostasis, and function of the CNS. Recent …