Abstract Chaperone-mediated autophagy (CMA), a proteolytic system contributing to the
degradation of intracellular proteins in lysosomes, is upregulated in tumors for pro …

Globally, cancer is affecting societies and is becoming an important cause of death.
Chemotherapy can be highly effective, but it is associated with certain problems, such as …

Idiopathic pulmonary fibrosis (IPF) is a devastating interstitial lung disease with a bleak
prognosis. Mounting evidence suggests that IPF shares bio-molecular similarities with lung …

Introduction Chirality is immanent in nature, and chiral molecules can achieve their
pharmacological action through chiral matching with biomolecules and molecular …

As alternatives to small-molecular proteolysis-targeting chimeras (PROTAC), peptide-based
molecular glues (MG) are a broad range of dual-functional ligands that simultaneously bind …

Chirality in biomolecules is ubiquitous in our world, but oral nanomedicines constructed from
chiral peptides are extremely rare, principally because of the immature nanofabrication and …

Compensation and intracellular storage of PD-L1 may compromise the efficacy of antibody
drugs targeting the conformational blockade of PD1/PD-L1 on the cell surface. Alternative …

Critical challenges remain in trauma emergency and surgical procedures involving liver
bleeding, particularly in perforating wounds that cannot be pressed and large wounds that …

Peptides have gained increasing interests as drug candidates in modern pharmaceutical
industry, however, the development of peptide drugs acting on intracellular targets is limited …

Objective: The low clinical utility of immune checkpoint inhibitors (ICIs) against PD-1 or PD-
L1 has recently been associated with the activation of the Wnt/β-catenin signaling pathway …