Atherosclerotic cardiovascular (CV) disease (ASCVD) incidence and mortality rates are
declining in many countries in Europe, but it is still a major cause of morbidity and mortality …

Introduction: Personalized diets based on an individual's genome to optimize the success of
dietary intervention and reduce genetic cardiovascular disease (CVD) risk, is one of the …

Objectives”, explains how to select and use various test methods for evaluating disease
states, the prognosis, and the effects of treatment. References to the literature published …

Background Although familial hypercholesterolemia (FH) is a severe monogenic disease, it
has been shown that clinical risk factors and common genetic variants can modify …

Sphingolipids (SLs) are structurally diverse lipids that are defined by the presence of a long-
chain base (LCB) backbone. Typically, LCBs contain a single Δ4E double bond (DB)(mostly …

Background Polypharmacy is a frequent condition, but its prevalence and determinants in
the Swiss mid-aged population are unknown. We aimed to evaluate the prevalence and …

PRSs can improve risk stratification for CAD especially in white/European populations and
have the potential to alter routine clinical care. However, unlocking this potential will require …

OBJECTIVE We evaluated whether the increasing number of genetic loci for coronary artery
disease (CAD) identified in the general population could be used to predict the risk of major …

Background: Cardiovascular disease is caused by a combination of genetic and
environmental risk factors. Some risk factors can change with age, but a genetic …

The present review deals with the stages of creation, methods of calculation, and the use of
a genetic risk score for coronary heart disease in various populations. The concept of risk …