[HTML][HTML] Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment
Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data
AA Connor, S Gallinger - Nature Reviews Cancer, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC), already among the deadliest epithelial
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …
[HTML][HTML] Spatially restricted drivers and transitional cell populations cooperate with the microenvironment in untreated and chemo-resistant pancreatic cancer
Pancreatic ductal adenocarcinoma is a lethal disease with limited treatment options and
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
poor survival. We studied 83 spatial samples from 31 patients (11 treatment-naïve and 20 …
[HTML][HTML] MACHETE identifies interferon-encompassing chromosome 9p21. 3 deletions as mediators of immune evasion and metastasis
The most prominent homozygous deletions in cancer affect chromosome 9p21. 3 and
eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis …
eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis …
The pancreatic cancer genome revisited
A Hayashi, J Hong… - … reviews Gastroenterology & …, 2021 - nature.com
Pancreatic cancer is a genetic disease, and the recurrent genetic alterations characteristic of
pancreatic cancer indicate the cellular processes that are targeted for malignant …
pancreatic cancer indicate the cellular processes that are targeted for malignant …
Management of patients with increased risk for familial pancreatic cancer: updated recommendations from the International Cancer of the Pancreas Screening (CAPS) …
M Goggins, KA Overbeek, R Brand, S Syngal… - Gut, 2020 - gut.bmj.com
Background and aim The International Cancer of the Pancreas Screening Consortium met in
2018 to update its consensus recommendations for the management of individuals with …
2018 to update its consensus recommendations for the management of individuals with …
ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung
Increasing evidence shows that cancer cells can disseminate from early evolved primary
lesions much earlier than the classical metastasis models predicted. Here, we reveal at a …
lesions much earlier than the classical metastasis models predicted. Here, we reveal at a …
[HTML][HTML] Single-cell transcriptomes of pancreatic preinvasive lesions and cancer reveal acinar metaplastic cells' heterogeneity
Y Schlesinger, O Yosefov-Levi, D Kolodkin-Gal… - Nature …, 2020 - nature.com
Acinar metaplasia is an initial step in a series of events that can lead to pancreatic cancer.
Here we perform single-cell RNA-sequencing of mouse pancreas during the progression …
Here we perform single-cell RNA-sequencing of mouse pancreas during the progression …
Cancer overdiagnosis: a biological challenge and clinical dilemma
For cancer screening to be successful, it should primarily detect cancers with lethal potential
or their precursors early, leading to therapy that reduces mortality and morbidity. Screening …
or their precursors early, leading to therapy that reduces mortality and morbidity. Screening …