Droplet-based microfluidics in biomedical applications

L Amirifar, M Besanjideh, R Nasiri, A Shamloo… - …, 2022 - iopscience.iop.org
Droplet-based microfluidic systems have been employed to manipulate discrete fluid
volumes with immiscible phases. Creating the fluid droplets at microscale has led to a …

Lipid in chips: a brief review of liposomes formation by microfluidics

G Zhang, J Sun - International journal of nanomedicine, 2021 - Taylor & Francis
Liposomes are ubiquitous tools in biomedical applications, such as drug delivery,
membrane science and artificial cell. Micro-and nanofabrication techniques have …

pH-controlled coacervate–membrane interactions within liposomes

MGF Last, S Deshpande, C Dekker - ACS nano, 2020 - ACS Publications
Membraneless organelles formed by liquid–liquid phase separation are dynamic structures
that are employed by cells to spatiotemporally regulate their interior. Indeed, complex …

Advanced microfluidic technologies for lipid nano-microsystems from synthesis to biological application

BG Carvalho, BT Ceccato, M Michelon, SW Han… - Pharmaceutics, 2022 - mdpi.com
Microfluidics is an emerging technology that can be employed as a powerful tool for
designing lipid nano-microsized structures for biological applications. Those lipid structures …

Can bottom-up synthetic biology generate advanced drug-delivery systems?

F Lussier, O Staufer, I Platzman, JP Spatz - Trends in Biotechnology, 2021 - cell.com
Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy
cells remains one of the most ambitious objectives in pharmacology. Nanomedicine, which …

Single-cell microfluidics facilitates the rapid quantification of antibiotic accumulation in Gram-negative bacteria

J Cama, M Voliotis, J Metz, A Smith, J Iannucci… - Lab on a Chip, 2020 - pubs.rsc.org
The double-membrane cell envelope of Gram-negative bacteria is a formidable barrier to
intracellular antibiotic accumulation. A quantitative understanding of antibiotic transport in …

The whole is bigger than the sum of its parts: drug transport in the context of two membranes with active efflux

VV Rybenkov, HI Zgurskaya, C Ganguly… - Chemical …, 2021 - ACS Publications
Cell envelope plays a dual role in the life of bacteria by simultaneously protecting it from a
hostile environment and facilitating access to beneficial molecules. At the heart of this ability …

Breaching the barrier: quantifying antibiotic permeability across gram-negative bacterial membranes

J Cama, AM Henney, M Winterhalter - Journal of Molecular Biology, 2019 - Elsevier
The double-membrane cell envelope of Gram-negative bacteria is a sophisticated barrier
that facilitates the uptake of nutrients and protects the organism from toxic compounds. An …

Current problems and future avenues in proteoliposome research

AM Amati, S Graf, S Deutschmann… - Biochemical Society …, 2020 - portlandpress.com
Membrane proteins (MPs) are the gatekeepers between different biological compartments
separated by lipid bilayers. Being receptors, channels, transporters, or primary pumps, they …

Lipid Microfluidic Biomimetic Models for Drug Screening: A Comprehensive Review

E Fernandes, VF Cardoso… - Advanced Functional …, 2024 - Wiley Online Library
Developing new drugs is a complex, time‐consuming, and expensive process, essential to
identify potential pharmacokinetic issues in the early stages to avoid investment in …