The UDP-glycosyltransferase (UGT) superfamily: new members, new functions, and novel paradigms
UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …
The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification
Human UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of …
[HTML][HTML] Gene therapy in patients with the Crigler–Najjar syndrome
Abstract Background Patients with the Crigler–Najjar syndrome lack the enzyme uridine
diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A1), the absence of which leads …
diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A1), the absence of which leads …
The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
PJ Bosma, JR Chowdhury, C Bakker… - … England Journal of …, 1995 - Mass Medical Soc
Background People with Gilbert's syndrome have mild, chronic unconjugated
hyperbilirubinemia in the absence of liver disease or overt hemolysis. Hepatic …
hyperbilirubinemia in the absence of liver disease or overt hemolysis. Hepatic …
Human UDP-glucuronosyltransferases: metabolism, expression, and disease
RH Tukey, CP Strassburg - Annual review of pharmacology and …, 2000 - annualreviews.org
In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …
Genome–microbiome interplay provides insight into the determinants of the human blood metabolome
Variation in the blood metabolome is intimately related to human health. However, few
details are known about the interplay between genetics and the microbiome in explaining …
details are known about the interplay between genetics and the microbiome in explaining …
Genetic Variants in the UDP-glucuronosyltransferase 1A1 Gene Predict the Risk of Severe Neutropenia of Irinotecan
F Innocenti, SD Undevia, L Iyer, P Xian Chen… - Journal of Clinical …, 2004 - ascopubs.org
Purpose Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-
glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucuronidation of the active …
glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucuronidation of the active …
Cytochrome P450 3A: ontogeny and drug disposition
The maturation of organ systems during fetal life and childhood exerts a profound effect on
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
drug disposition. The maturation of drug-metabolising enzymes is probably the predominant …
Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active …
L Iyer, CD King, PF Whitington… - The Journal of …, 1998 - Am Soc Clin Investig
Irinotecan (CPT-11) is a promising antitumor agent, recently approved for use in patients
with metastatic colorectal cancer. Its active metabolite, SN-38, is glucuronidated by hepatic …
with metastatic colorectal cancer. Its active metabolite, SN-38, is glucuronidated by hepatic …
Portosystemic shunt placement reveals blood signatures for the development of hepatic encephalopathy through mass spectrometry
Elective transjugular intrahepatic portosystemic shunt (TIPS) placement can worsen
cognitive dysfunction in hepatic encephalopathy (HE) patients due to toxins, including …
cognitive dysfunction in hepatic encephalopathy (HE) patients due to toxins, including …