Oxidative stress emerges as a critical mechanism underlying the development and
progression of various brain diseases, arising from either increased generation of reactive …

Plasmodium falciparum causes the most severe and fatal form of malaria in humans with
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …

BACKGROUND Cerebral malaria (CM) accounts for nearly 400,000 deaths annually in
African children. Current dogma suggests that CM results from infected RBC (iRBC) …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …

Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and
its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach …

Infectious diseases of different etiologies have been associated with acute and long-term
neurological consequences. The primary cause of these consequences appears to be an …

Cerebral malaria (CM) is a severe neurological complication caused by Plasmodium
falciparum parasites; it is characterized by the sequestration of infected red blood cells …

Plasmodium falciparum infections can cause severe malaria, but not every infected person
develops life-threatening complications. In particular, carriers of the structural …

Astrocytes and microglia are activated during cerebral malaria (CM) and contribute to the
production and release of several mediators during neuroinflammatory processes. Whether …

Human cerebral malaria (HCM) is a serious complication of Plasmodium falciparum
infection. The most severe outcomes for patients include coma, permanent neurological …