The ASK1-signalosome→ p38 MAPK and SAPK/JNK signaling networks promote
senescence (in vitro) and aging (in vivo, animal models and human cohorts) in response to …

Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

Cirrhotic cardiomyopathy is a clinical syndrome in patients with liver cirrhosis characterized
by an abnormal and blunted response to physiologic, pathologic, or pharmacologic stress …

Intracellular MAPK (mitogen-activated protein kinase) signalling cascades probably play an
important role in the pathogenesis of cardiac and vascular disease. A substantial amount of …

Importance p38 Mitogen-activated protein kinase (MAPK)–stimulated inflammation is
implicated in atherogenesis, plaque destabilization, and maladaptive processes in …

Patients with primary (AL) cardiac amyloidosis suffer from progressive cardiomyopathy with
a median survival of less than 8 months and a 5-year survival of< 10%. Contributing to this …

Cardiovascular diseases, the number 1 cause of death worldwide, are frequently associated
with apoptotic death of cardiac myocytes. Since cardiomyocyte apoptosis is a highly …

Mitogen-activated protein (MAP) kinases belong to a highly conserved family of Ser-Thr
protein kinases in the human kinome and have diverse roles in broad physiological …

Abstract p38 kinases are members of the mitogen-activated protein kinases (MAPK) with
established contribution to a wide range of signaling pathways and different biological …

AMP-activated protein kinase (AMPK) promotes glucose transport, maintains ATP stores,
and prevents injury and apoptosis during ischemia. AMPK has several direct molecular …