BACKGROUND Diabetic foot ulcers are a common diabetic complication leading to
alarming figures of amputation, disability, and early mortality. The diabetic glucooxidative …

Renewed interest in immune cell metabolism has led to the emergence of a research field
aimed at studying the importance of metabolic processes for an effective immune response …

Fibrosis is the final common pathway leading to end-stage renal failure. By analyzing the
kidneys of patients and animal models with fibrosis, we observed a significant mitochondrial …

Metabolic reprogramming powers and polarizes macrophage functions, but the nature and
regulation of this response during infection with pathogens remain controversial. In this …

Aims To describe characteristics of COVID-19 patients with type 2 diabetes and to analyze
risk factors for severity. Methods Demographics, comorbidities, symptoms, laboratory …

Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates.
Advancement in modern medicine and establishment of separate branches of medical …

The innate immune system is an evolutionarily conserved system that senses and defends
against infection and irritation. Innate immune signaling is a complex cascade that quickly …

Immune cells are bioenergetically expensive during activation, which requires tightly
regulated control of metabolic pathways. Both low and high glycemic conditions can …

Tissue damage triggers a rapid and robust inflammatory response in order to clear and
repair a wound. Remarkably, many of the cell biology features that underlie the ability of …

The ubiquitous gasotransmitter hydrogen sulfide (H2S) has been recognized to play a
crucial role in human health. Using cystathionine γ-lyase (CSE)-deficient mice, we …