Ischemic disease is a class of diseases in which an organ is ischemic due to vascular
occlusion, a major contributor to death and disability worldwide. However, when the blood …

Epigenetics has provided a new dimension to our understanding of nuclear factor erythroid
2–related factor 2/Kelch-like ECH-associated protein 1 (human NRF2/KEAP1 and murine …

Simple Summary Several studies showed that oxidative stress is involved in cancer
occurrence, development, progression chemoresistance and radio resistance. The nuclear …

Incidence rate of cancer is estimated to increase by 40% in 2030. Furthermore, the
development of resistance against currently available treatment strategies has contributed to …

Prostate cancer is the second most diagnosed form of cancer in men worldwide and
accounted for roughly 1.3 million cases and 359,000 deaths globally in 2018, despite all the …

Simple Summary Epigenetics has provided a new dimension to our understanding of cancer
initiation and progression. Unlike the genetic changes in DNA sequence, abnormal …

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) and its negative
regulator kelch-like ECH-associated protein 1 (KEAP1) regulate various genes involved in …

Reactive oxygen species (ROS) induce multiple signaling cascades in the cell and hence
play an important role in the regulation of the cell's fate. ROS can cause irreversible damage …

Throughout life, organisms are exposed to various exogenous and endogenous factors that
cause DNA damages and somatic mutations provoking genomic instability. At a young age …

Oxidative stress, an imbalance between reactive oxygen species and antioxidants, has been
seen in the pathological states of many disorders such as ischemic diseases and cancers …