Our understanding of the ubiquitin code has greatly evolved from conventional E1, E2 and
E3 enzymes that modify Lys residues on specific substrates with a single type of ubiquitin …

Tissue-resident macrophages (TRMs) are heterogeneous populations originating either
from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid …

Cancer associated fibroblasts (CAFs) and tumor associated macrophages (TAMs) are
among the most important and abundant players of the tumor microenvironment. CAFs as …

Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …

To study the spatial interactions among cancer and non-cancer cells 1, we here examined a
cohort of 131 tumour sections from 78 cases across 6 cancer types by Visium spatial …

ISG15, the product of interferon (IFN)-stimulated gene 15, is the first identified ubiquitin-like
protein (UBL), which plays multifaceted roles not only as a free intracellular or extracellular …

Colorectal cancer (CRC) represents 10% of all cancer types, making it the third leading
cause of cancer-related deaths globally. Metastasis is the primary factor causing mortality in …

Background Nasopharyngeal carcinoma (NPC) is a head and neck malignant tumor with a
high incidence and recurrence rate. The crosstalk between ferroptosis and tumor-associated …

Engineered T cells transiently expressing tumor-targeting receptors are an attractive form of
engineered T cell therapy as they carry no risk of insertional mutagenesis or long-term …

Abstract Glucose-6-phosphate dehydrogenase (G6PD) is involved in triple-negative breast
cancer (TNBC) progression. Metabolic crosstalk between cancer cells and tumor-associated …