Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …

Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Summary N 6-methyladenosine (m 6 A) affects multiple aspects of mRNA metabolism and
regulates developmental transitions by promoting mRNA decay. Little is known about the …

Autophagy and apoptosis are two crucial self-destructive processes that maintain cellular
homeostasis, which are characterized by their morphology and regulated through signal …

Defining the multiple roles of the mechanistic (formerly'mammalian') target of rapamycin
(mTOR) signalling pathway in neurological diseases has been an exciting and rapidly …

TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic
target of rapamycin) was activated and then up-regulated in injured axons, owing to local …

N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …

A formidable challenge in neural repair in the adult central nervous system (CNS) is the long
distances that regenerating axons often need to travel in order to reconnect with their …

Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …