Energy metabolism in ALS: an underappreciated opportunity?

T Vandoorne, K De Bock, L Van Den Bosch - Acta neuropathologica, 2018 - Springer
Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive and fatal
neurodegenerative disorder that primarily affects motor neurons. Despite our increased …

Risk factors and emerging therapies in amyotrophic lateral sclerosis

N Nowicka, J Juranek, JK Juranek… - International journal of …, 2019 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease
characterized by a permanent degeneration of both upper and lower motor neurons. Many …

Effect of high‐caloric nutrition on survival in amyotrophic lateral sclerosis

AC Ludolph, J Dorst, J Dreyhaupt… - Annals of …, 2020 - Wiley Online Library
Objective Weight loss has been identified as a negative prognostic factor in amyotrophic
lateral sclerosis, but there is no evidence regarding whether a high‐caloric diet increases …

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice

M Wong, LJ Martin - Human molecular genetics, 2010 - academic.oup.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of motor neurons
(MNs) that causes skeletal muscle paralysis. Familial forms of ALS are linked to mutations in …

Hypothalamic atrophy is related to body mass index and age at onset in amyotrophic lateral sclerosis

M Gorges, P Vercruysse, HP Müller… - Journal of Neurology …, 2017 - jnnp.bmj.com
Objective Our objective was to study the hypothalamic volume in a cohort of patients with
amyotrophic lateral sclerosis (ALS) including symptomatic and presymptomatic ALS …

Metabolic abnormalities, dietary risk factors and nutritional management in amyotrophic lateral sclerosis

E D'Amico, G Grosso, JW Nieves, A Zanghì… - Nutrients, 2021 - mdpi.com
Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative
disease that affects motor neurons, leading to a relentless paralysis of skeletal muscles and …

Amyotrophic lateral sclerosis and frontotemporal dementia: distinct and overlapping changes in eating behaviour and metabolism

RM Ahmed, M Irish, O Piguet, GM Halliday… - The Lancet …, 2016 - thelancet.com
Metabolic changes incorporating fluctuations in weight, insulin resistance, and cholesterol
concentrations have been identified in several neurodegenerative disorders. Whether these …

Diet, microbiota and brain health: unraveling the network intersecting metabolism and neurodegeneration

F Gentile, PE Doneddu, N Riva… - International journal of …, 2020 - mdpi.com
Increasing evidence gives support for the idea that extra-neuronal factors may affect brain
physiology and its predisposition to neurodegenerative diseases. Epidemiological and …

[HTML][HTML] A plural role for lipids in motor neuron diseases: energy, signaling and structure

F Schmitt, G Hussain, L Dupuis, JP Loeffler… - Frontiers in cellular …, 2014 - frontiersin.org
Motor neuron diseases (MNDs) are characterized by selective death of motor neurons and
include mainly adult-onset amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy …

Nutritional and metabolic factors in amyotrophic lateral sclerosis

A Ludolph, L Dupuis, E Kasarskis, F Steyn… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease that is
classically thought to impact the motor system. Over the past 20 years, research has started …