Restoring inflammatory mediator balance after sofosbuvir‐induced viral clearance in patients with chronic hepatitis C

GN Saraiva, NF Rosário, T Medeiros… - Mediators of …, 2018 - Wiley Online Library
This study aimed at analyzing circulating levels of inflammatory and profibrogenic cytokines
in patients with hepatitis C virus (HCV) chronic infection undergoing therapy with direct …

Interleukin-6 gene polymorphisms and susceptibility to liver diseases: a meta-analysis

X Wang, Z Yan, Q Ye - Medicine, 2019 - journals.lww.com
Background: Several studies have explored the associations between interleukin-6 (IL-6)
gene polymorphisms and the susceptibility to liver diseases, however, results remain …

Interleukin-6 polymorphisms in HCC patients chronically infected with HCV

F Adnan, NU Khan, A Iqbal, I Ali, A Petruzziello… - Infectious agents and …, 2020 - Springer
Hepatocellular carcinoma is a primary liver malignancy in which the risk of development is
always multifunctional. Interleukin-6 is a proinflammatory and multifunctional cytokine, which …

Cytokine profile during occult hepatitis B virus infection in chronic hepatitis C patients

CRA Ribeiro, NAA de Almeida, KG Martinelli, MA Pires… - Virology Journal, 2021 - Springer
Background The hepatitis B virus (HBV) is one of the leading causes of acute, chronic and
occult hepatitis (OBI) representing a serious public health threat. Cytokines are known to be …

Remodeling of immunological biomarkers in patients with chronic hepatitis C treated with direct-acting antiviral therapy

IG Ribeiro, JGA Coelho-dos-Reis, JRB Fradico… - Antiviral Research, 2021 - Elsevier
The HCV treatment with DAAs has offered a unique opportunity to analyze the changes in
the immune system caused by the rapid inhibition of viral replication. We sought to analyze …

The impact of HCV eradication on hyperglycemia, insulin resistance, cytokine production, and insulin receptor substrate-1 and 2 expression in patients with HCV …

B Mahmoud, AA Moneim, D Mabrouk - Clinical and Experimental Medicine, 2022 - Springer
Virological responses after hepatitis C virus (HCV) treatment may alleviate liver disease and
extra-hepatic manifestations. Our study aims to explore the impact of HCV eradication on the …

Role of Inflammatory/immune response and cytokine polymorphisms in the severity of chronic hepatitis C (CHC) before and after direct acting antiviral (DAAs) …

J Ferreira, M Oliveira, M Bicho, F Serejo - International journal of …, 2023 - mdpi.com
Host regulatory immune response is involved in the hepatic inflammatory process caused by
the hepatitis C virus (HCV). We aimed to determine if HCV clearance with direct-acting …

Effect of Chronic Hepatitis C on the Activity of the Membrane Transporters P‐gp and OATP1B1/BCRP on Patients With Different Stages of Hepatic Fibrosis

LF Pippa, CP Vieira, JA Caris, A Rocha… - Clinical …, 2023 - Wiley Online Library
The activity of the membrane transporters organic anion‐transporting polypeptide 1B1
(OATP1B1) & breast cancer resistance protein (BCRP)(rosuvastatin) and P‐glycoprotein (P …

Association of TNF− 1031 C/C as a potential protection marker for leprosy development in Amazonas state patients, Brazil

GAV Silva, R Ramasawmy, AL Boechat, AC Morais… - Human Immunology, 2015 - Elsevier
Polymorphisms present in the TNF promoter region has shown to influence the gene
transcription. Leprosy displays different clinical manifestations according to the immune …

Liver Fibrosis Stages Affect Organic Cation Transporter 1/2 Activities in Hepatitis C Virus-Infected Patients

MDL Thomaz, CP Vieira, JA Caris, MP Marques… - Pharmaceuticals, 2024 - mdpi.com
This study aims to evaluate the impact of liver fibrosis stages of chronic infection with
hepatitis C virus (HCV) on the in vivo activity of organic cation transporters (hepatic OCT1 …