Gene silencing in cancer in association with promoter hypermethylation
This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …
[HTML][HTML] Molecular and cellular heterogeneity in breast cancer: challenges for personalized medicine
AG Rivenbark, SM O'Connor, WB Coleman - The American journal of …, 2013 - Elsevier
Breast cancer is noted for disparate clinical behaviors and patient outcomes, despite
common histopathological features at diagnosis. Molecular pathogenesis studies suggest …
common histopathological features at diagnosis. Molecular pathogenesis studies suggest …
World Health Organization classification of tumours: Pathology & genetics of tumours of the urinary system and male genital organs
TY Chan - Urology, 2005 - goldjournal.net
This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …
[HTML][HTML] The epigenetics of breast cancer
J Jovanovic, JA Rønneberg, J Tost, V Kristensen - Molecular oncology, 2010 - Elsevier
Epigenetic changes can be defined as stable molecular alterations of a cellular phenotype
such as the gene expression profile of a cell that are heritable during somatic cell divisions …
such as the gene expression profile of a cell that are heritable during somatic cell divisions …
DNA methylation and breast carcinogenesis
M Widschwendter, PA Jones - Oncogene, 2002 - nature.com
Abstract Knowledge about breast carcinogenesis has accumulated during the last decades
but has barely been translated into strategies for early detection or prevention of this …
but has barely been translated into strategies for early detection or prevention of this …
DNA methylation markers in colorectal cancer
MS Kim, J Lee, D Sidransky - Cancer and Metastasis Reviews, 2010 - Springer
Colorectal cancer (CRC) arises as a consequence of the accumulation of genetic and
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …
epigenetic alterations in colonic epithelial cells during neoplastic transformation. Epigenetic …
The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation
L Shivakumar, J Minna, T Sakamaki… - … and cellular biology, 2002 - Taylor & Francis
The RASSF1A locus at 3p21. 3 is epigenetically inactivated at high frequency in a variety of
solid tumors. Expression of RASSF1A is sufficient to revert the tumorigenicity of human …
solid tumors. Expression of RASSF1A is sufficient to revert the tumorigenicity of human …
Role of the Ras-association domain family 1 tumor suppressor gene in human cancers
A Agathanggelou, WN Cooper, F Latif - Cancer research, 2005 - AACR
In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated
frequently by epigenetic events rather than classic mutation/deletion events has been …
frequently by epigenetic events rather than classic mutation/deletion events has been …
[HTML][HTML] The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells
DNA CpG methylation can cooperate with histone H3 lysine 9 (H3-K9) methylation in
heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently …
heterochromatin formation and gene silencing. Trimethylation of H3-K9 by the recently …
Tumor suppressor genes on chromosome 3p involved in the pathogenesis of lung and other cancers
ER Zabarovsky, MI Lerman, JD Minna - Oncogene, 2002 - nature.com
Loss of heterozygosity (LOH) involving several chromosome 3p regions accompanied by
chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than …
chromosome 3p deletions are detected in almost 100% of small (SCLCs) and more than …