Telomerase is the essential reverse transcriptase required for linear chromosome
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …

Current approaches for inserting autonomous transgenes into the genome, such as CRISPR–
Cas9 or virus-based strategies, have limitations including low efficiency and high risk of …

Active telomerase is essential for stem cells and most cancers to maintain telomeres. The
enzymatic activity of telomerase is related but not equivalent to the expression of TERT, the …

Recent progress has greatly increased the understanding of telomere-bound shelterin
proteins and the telomerase holoenzyme, predominantly as separate complexes …

The vast body of literature regarding human telomere maintenance is a true testament to the
importance of understanding telomere regulation in both normal and diseased states. In this …

Telomerase activity imparts eukaryotic cells with unlimited proliferation capacity, one of the
cancer hallmarks. Over 90% of human urothelial carcinoma of the bladder (UCB) tumours …

BACKGROUND Eukaryotic chromosomal ends are linear and are protected by
nucleoprotein complexes known as telomeres. The complex structural anatomy and the …

We dissected the importance of human telomerase biogenesis and trafficking pathways for
telomere maintenance. Biological stability of human telomerase RNA (hTR) relies on H/ACA …

Telomerase is a specialized reverse transcriptase that uses an intrinsic RNA subunit as the
template for telomeric DNA synthesis. Biogenesis of human telomerase requires its RNA …