Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …

METHODS—A Medline search without limitations of date (as of October 2005), language, or
humans was carried out by the authors. The following medical subject headings were …

Chronic infection with the hepatitis C virus (HCV) is a major risk factor for the development of
hepatocellular carcinoma (HCC) worldwide. The pathogenesis of HCC in HCV infection has …

Hepatocellular carcinoma (HCC) is one of the human cancers clearly linked to viral
infections. Although the major viral and environmental risk factors for HCC development …

The major risk factors and etiological agents responsible for development of hepatocellular
carcinoma in humans have been identified and characterized. Among these are chronic …

Hepatocellular carcinoma (HCC) is the fifth commonest malignancy worldwide and its
incidence is rising. Surgery, including transplantation, remains the only potentially curative …

Diabetes mellitus is the fifth leading cause of death in the United States; 17 million people
are affected. Liver disease is one of the leading causes of death in persons with type 2 …

We investigated the angiogenic phenotype of regenerative and dysplastic hepatocellular
nodules to assess whether these lesions have distinct vascular profiles compared with the …

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Cirrhosis
caused by hepatitis B virus, hepatitis C virus or chronic alcohol intake is associated with …

Recent progress in cancer genome analysis using next-generation sequencing has
revealed a high mutation burden in some tumors. The particularly high rate of somatic …