Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …

The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …

As the second most common age related neurodegenerative disease after Alzheimer's
disease, the health, social and economic impact resulting from Parkinson's disease will …

The brain neuronal systems defined by the neurotransmitter dopamine (DA) have since long
a recognized role in the regulation of motor functions. More recently, converging evidence …

Molecular-imaging studies of dopaminergic neurotransmission measure biomarkers of
dopamine (DA), such as the DA transporter and D1 and D2 receptor densities in the living …

Parkinson's disease (PD) is a multifocal degenerative disorder for which there is no cure.
The majority of cases are sporadic with unknown etiology. Recent data indicate that …

Background and rationale Reinstatement of the function of working memory, the cardinal
cognitive process essential for human reasoning and judgment, is potentially the most …

The default mode network (DMN) is a set of functionally connected brain regions which
shows deactivation (task-induced deactivation, TID) during a cognitive task. Evidence shows …

Chronic systemic complex I inhibition caused by rotenone exposure induces features of
Parkinson's disease (PD) in rats, including selective nigrostriatal dopaminergic …

Brain aging is characterized by considerable heterogeneity, including varying degrees of
dysfunction in specific brain systems, notably a medial temporal lobe memory system and a …