Abstract TP53 (p53) is the single most frequently altered gene in human cancers, with
mutations being present in approximately 50% of all invasive tumours. However, in some of …

Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all
multicellular organisms to control cell proliferation and maintain tissue homeostasis as well …

Ovarian cancer is the deadliest gynecologic malignancy, with a 5-year survival rate of
approximately 47%, a number that has remained constant over the past two decades. Early …

The tumor suppressor p53 has established functions in cancer. Specifically, it has been
shown to cause cell-cycle arrest and apoptosis in response to DNA damage. It is also one of …

More than 50% of human tumors carry TP 53 gene mutations and in consequence more
than 45,000 somatic and germline mutations have been gathered in the UMD TP 53 …

Simple Summary This review describes in a very detailed and exhaustive approach the
literature of these last 20 years on glioblastoma targeted therapies in Phases II-IV of 257 …

Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural
active ingredient with various biological activities, such as anti-cancer, anti-inflammatory …

Highlights•Temozolomide resistance can be induced by glioblastoma cells.•Resistance to
temozolomide is caused by multiple mechanisms.•Different resistance pathways exist in …

Phototherapy is universally recognized as the first option for treating neonatal jaundice due
to its unparalleled efficiency and safety in reducing the high serum free bilirubin levels and …

Abstract Since Mdm2 (Mouse double minute 2) inhibitors show serious toxicity in clinic
studies, different approaches to achieve therapeutic reactivation of p53-mediated tumor …