Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and
BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for …

The ATM gene is mutated in the syndrome, ataxia-telangiectasia (AT), which is
characterized by predisposition to cancer. Patients with AT have an elevated risk of breast …

Ataxia telangiectasia mutated (ATM) is a key gene in DNA double-strand break (DSB), and
therefore, most of its disabling genetic alterations play an important initiative role in many …

Brain tumors are becoming a major cause of death. The classification of brain tumors has
gone through restructuring with regard to some criteria such as the presence or absence of a …

Abstract Cyclin D2, P53, Rb and ATM as cell cycle genes regulate cell growth and
proliferation. Considering their roles, we assumed that they have different level of mRNA …

Historically, clinicians made observations in their clinical practice regarding certain
associations of specific central nervous system (CNS) tumors and other clinical findings …

The involvement of ATM gene and specifically, the important role of D1853N polymorphism,
as a three-hit hypothesis has been previously reported in an Iranian proband affected with …

BACKGROUND Although circulating tumor cells (CTCs) have been the focus of
consideration for a decade, a categorized cell-based diagnostic strategy is unavailable. The …

It was previously reported that tumour samples had shorter telomeres than the surrounding
normal tissue. Hereby, the initial sign of correlation between malignant tissue and telomere …

Ataxia-telangiectasia (AT) is a rare autosomal recessive disease, affecting neurologic and
immune system. Numerous mutations are described in the ATM gene in several populations …