Enhanced signaling through RAS and the mitogen‐associated protein kinase (MAPK)
cascade underlies the RASopathies, a family of clinically related disorders affecting …

RAS GTPases control a major signaling network implicated in several cellular functions,
including cell fate determination, proliferation, survival, differentiation, migration, and …

We report germline loss-of-function mutations in SPRED1 in a newly identified autosomal
dominant human disorder. SPRED1 is a member of the SPROUTY/SPRED family of proteins …

Upregulated signal flow through RAS and the mitogen-associated protein kinase (MAPK)
cascade is the unifying mechanistic theme of the RASopathies, a family of disorders …

The Ras/mitogen-activated protein kinase (MAPK) pathway plays a critical role in
transducing mitogenic signals from receptor tyrosine kinases. Loss-of-function mutations in …

Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disease affecting
about 2% of the general population. It is characterized by persistent intrusive thoughts and …

The roles of SPRED proteins in signaling, development, and cancer are becoming
increasingly recognized. SPRED proteins comprise an N-terminal EVH-1 domain, a central c …

Spreds form a new protein family with an N‐terminal Enabled/VASP homology 1 domain
(EVH1), a central c‐Kit binding domain (KBD) and a C‐terminal Sprouty‐related domain …

Miniaturization has occurred in many animal lineages, including insects and vertebrates, as
a widespread trend during animal evolution. Among Hymenoptera, miniaturization has taken …

HIP14 is the most highly conserved of 23 human palmitoyl acyltransferases (PATs) that
catalyze the post-translational addition of palmitate to proteins, including huntingtin (HTT) …