Astrocytic transcriptional and epigenetic mechanisms of drug addiction
LM Holt, EJ Nestler - Journal of Neural Transmission, 2024 - Springer
Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …
current neuroscience research. Drug-induced lasting changes in gene expression are …
The genetics of bipolar disorder with obesity and type 2 diabetes
Background Bipolar disorder (BD) presents with high obesity and type 2 diabetes (T2D) and
pathophysiological and phenomenological abnormalities shared with cardiometabolic …
pathophysiological and phenomenological abnormalities shared with cardiometabolic …
Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior
LM Szewczyk, MA Lipiec, E Liszewska, K Meyza… - Molecular …, 2024 - nature.com
The Wnt/β-catenin pathway contains multiple high-confidence risk genes that are linked to
neurodevelopmental disorders, including autism spectrum disorder. However, its ubiquitous …
neurodevelopmental disorders, including autism spectrum disorder. However, its ubiquitous …
Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis
BACKGROUND: Dilated cardiomyopathy (DCM) is a major cause of heart failure and carries
a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly …
a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly …
[HTML][HTML] Heightened inflammation in bipolar disorder occurs independent of symptom severity and is explained by body mass index
Inflammation is hypothesized to be a key component of bipolar disorder (BP) development
and progression. However, findings linking BP prevalence and symptomology to immune …
and progression. However, findings linking BP prevalence and symptomology to immune …
What we know about the role of corticosteroids in psychiatric disorders; evidence from animal and clinical studies
F Dabbah-Assadi, R Handel, A Shamir - Journal of Psychiatric Research, 2022 - Elsevier
Corticosteroids, often known as steroids, are anti-inflammatory medicine prescribed for
various conditions. There is accumulating evidence of immune dysregulation in major …
various conditions. There is accumulating evidence of immune dysregulation in major …
In vitro modeling of glucocorticoid mechanisms in stress-related mental disorders: Current challenges and future perspectives
K Bassil, L De Nijs, BPF Rutten… - Frontiers in Cell and …, 2022 - frontiersin.org
In the last decade, in vitro models has been attracting a great deal of attention for the
investigation of a number of mechanisms underlying neurological and mental disorders …
investigation of a number of mechanisms underlying neurological and mental disorders …
TCF7L2: a potential key regulator of antidepressant effects on hippocampal astrocytes in depression model mice
Y Koga, N Kajitani, K Miyako, H Takizawa… - Journal of Psychiatric …, 2024 - Elsevier
Clinical and preclinical studies suggest that hippocampal astrocyte dysfunction is involved in
the pathophysiology of depression; however, the underlying molecular mechanisms remain …
the pathophysiology of depression; however, the underlying molecular mechanisms remain …
Exploring noncoding variants in genetic diseases: from detection to functional insights
Previous studies on genetic diseases predominantly focused on protein-coding variations,
overlooking the vast noncoding regions in the human genome. The development of high …
overlooking the vast noncoding regions in the human genome. The development of high …
Long noncoding RNAs in induced pluripotent stem cells and their differentiation
M Ilieva, S Uchida - American Journal of Physiology-Cell …, 2022 - journals.physiology.org
The breakthrough technology for reprogramming somatic cells into induced pluripotent stem
cells (iPSCs) has created a new path for science and medicine. The iPSC technology …
cells (iPSCs) has created a new path for science and medicine. The iPSC technology …