Addiction is a leading cause of disease burden worldwide and remains a challenge in
current neuroscience research. Drug-induced lasting changes in gene expression are …

Background Bipolar disorder (BD) presents with high obesity and type 2 diabetes (T2D) and
pathophysiological and phenomenological abnormalities shared with cardiometabolic …

The Wnt/β-catenin pathway contains multiple high-confidence risk genes that are linked to
neurodevelopmental disorders, including autism spectrum disorder. However, its ubiquitous …

BACKGROUND: Dilated cardiomyopathy (DCM) is a major cause of heart failure and carries
a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly …

Inflammation is hypothesized to be a key component of bipolar disorder (BP) development
and progression. However, findings linking BP prevalence and symptomology to immune …

Corticosteroids, often known as steroids, are anti-inflammatory medicine prescribed for
various conditions. There is accumulating evidence of immune dysregulation in major …

In the last decade, in vitro models has been attracting a great deal of attention for the
investigation of a number of mechanisms underlying neurological and mental disorders …

Clinical and preclinical studies suggest that hippocampal astrocyte dysfunction is involved in
the pathophysiology of depression; however, the underlying molecular mechanisms remain …

Previous studies on genetic diseases predominantly focused on protein-coding variations,
overlooking the vast noncoding regions in the human genome. The development of high …

The breakthrough technology for reprogramming somatic cells into induced pluripotent stem
cells (iPSCs) has created a new path for science and medicine. The iPSC technology …