SARS-CoV-2 Mpro: A Potential Target for Peptidomimetics and Small-Molecule Inhibitors
A Citarella, A Scala, A Piperno, N Micale - Biomolecules, 2021 - mdpi.com
The uncontrolled spread of the COVID-19 pandemic caused by the new coronavirus SARS-
CoV-2 during 2020–2021 is one of the most devastating events in the history, with …
CoV-2 during 2020–2021 is one of the most devastating events in the history, with …
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ2,4-amino acids targeting the SARS-CoV-2 main protease
Abstract γ-Amino acids can play important roles in the biological activities of natural
products; however, the ribosomal incorporation of γ-amino acids into peptides is …
products; however, the ribosomal incorporation of γ-amino acids into peptides is …
Structure-based drug design of an inhibitor of the SARS-CoV-2 (COVID-19) main protease using free software: A tutorial for students and scientists
This paper describes the structure-based design of a preliminary drug candidate against
COVID-19 using free software and publicly available X-ray crystallographic structures. The …
COVID-19 using free software and publicly available X-ray crystallographic structures. The …
Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors
Specific anti-coronaviral drugs complementing available vaccines are urgently needed to
fight the COVID-19 pandemic. Given its high conservation across the betacoronavirus genus …
fight the COVID-19 pandemic. Given its high conservation across the betacoronavirus genus …
A ricin-based peptide BRIP from Hordeum vulgare inhibits Mpro of SARS-CoV-2
P Kashyap, VK Bhardwaj, M Chauhan, V Chauhan… - Scientific Reports, 2022 - nature.com
COVID-19 pandemic caused by SARS-CoV-2 led to the research aiming to find the inhibitors
of this virus. Towards this world problem, an attempt was made to identify SARS-CoV-2 main …
of this virus. Towards this world problem, an attempt was made to identify SARS-CoV-2 main …
Identification of a Putative SARS-CoV-2 Main Protease Inhibitor through In Silico Screening of Self-Designed Molecular Library
N Liu, Z Yang, Y Liu, X Dang, Q Zhang, J Wang… - International journal of …, 2023 - mdpi.com
There have been outbreaks of SARS-CoV-2 around the world for over three years, and its
variants continue to evolve. This has become a major global health threat. The main …
variants continue to evolve. This has become a major global health threat. The main …
[HTML][HTML] Repurposing an antiviral drug against SARS‐CoV‐2 main protease
This article highlights recent pioneering work by Günther et al. towards the discovery of
potential repurposed antiviral compounds (peptidomimetic and non‐peptidic) against the …
potential repurposed antiviral compounds (peptidomimetic and non‐peptidic) against the …
Computer-aided screening for potential coronavirus 3-chymotrypsin-like protease (3CLpro) inhibitory peptides from putative hemp seed trypsinized peptidome
K Prasertsuk, K Prongfa, P Suttiwanich, N Harnkit… - Molecules, 2022 - mdpi.com
To control the COVID-19 pandemic, antivirals that specifically target the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently required. The 3 …
respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently required. The 3 …
Structure-guided design of potent inhibitors of SARS-CoV-2 3CL protease: structural, biochemical, and cell-based studies
The COVID-19 pandemic is having a major impact on public health worldwide, and there is
an urgent need for the creation of an armamentarium of effective therapeutics, including …
an urgent need for the creation of an armamentarium of effective therapeutics, including …
Cyclic β2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease
T Miura, TR Malla, L Brewitz, A Tumber… - Bulletin of the …, 2024 - academic.oup.com
Due to their constrained conformations, cyclic β2, 3-amino acids (cβAA) are key building
blocks that can fold peptides into compact and rigid structures, improving peptidase …
blocks that can fold peptides into compact and rigid structures, improving peptidase …