Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

Recent studies call into question the necessity of hypertrophic growth of the heart as a
“compensatory” response to hemodynamic stress. These findings, coupled with recent …

This review focuses mainly on studies in non-ischemic animal models of heart failure. These
animals develop ventricular arrhythmias, mostly non-sustained ventricular tachycardia, and …

This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …

The animal models of myocardial injury induced by systemic β-adrenergic receptor agonist
administration represent an experimental approach of persisting interest. These models …

Background—Cardiac hypertrophy underlies arrhythmias and sudden death, for which
mineralocorticoid receptor (MR) activity has recently been implicated. We sought to establish …

Background—Ventricular arrhythmias are life-threatening complications of heart failure and
myocardial ischemia. Increased diastolic Ca2+ overload occurring in ischemia leads to …

Left ventricular hypertrophy (LVH) is associated with electric remodeling and increased
arrhythmia risk, although the underlying mechanisms are poorly understood. In the …

Action potential (AP) prolongation is a hallmark of failing myocardium. Functional
downregulation of K currents is a prominent feature of cells isolated from failing ventricles …

Angiotensin II (ANG II) increases oxidative stress and is associated with increased risk of
sudden cardiac death. The cardiac Na+ channel promoter contains elements that confer …