Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important
role in the maintenance of wakefulness, and dysfunction in the histaminergic system has …

Many neurochemical systems interact to generate wakefulness and sleep. Wakefulness is
promoted by neurons in the pons, midbrain, and posterior hypothalamus that produce …

The third histamine receptor was discovered in 1983 by a traditional pharmacological
approach, consisting of assessing the inhibitory effect of histamine on its own release from …

The histamine H3 receptor, first described in 1983 as a histamine autoreceptor and later
shown to also function as a heteroreceptor that regulates the release of other …

Histamine has long been known to trigger allergic reactions and gastric acid secretion.
However, it was later discovered that, in the brain, histamine regulates basic homeostatic …

Narcolepsy is characterized by excessive daytime sleepiness (EDS), cataplexy, direct
onsets of rapid eye movement (REM) sleep from wakefulness (DREMs) and deficiency of …

H3 antagonists increase the release of brain histamine, acetylcholine, noradrenaline, and
dopamine, neurotransmitters that are known to modulate cognitive processes. The ability to …

As the population ages, there is a growing need for effective therapies for the treatment of
neurological diseases. A limited number of therapeutics are currently available to improve …

This article provides an overview of compounds based on imidazo [1, 2-a] pyridine, imidazo
[1, 5-a] pyridine, imidazo [4, 5-b] pyridine and imidazo [4, 5-c] pyridine scaffolds, which act as …