Many first-line treatments for neglected tropical diseases identified by the World Health
Organization (WHO) are limited by one or more of the following: the development of drug …

The widespread use of antibiotics has resulted in the emergence of drug-resistant
populations of microorganisms. Clearly, one can see the need to develop new, more …

Ruthenium is seldom mentioned in microbiology texts, due to the fact that this metal has no
known, essential roles in biological systems, nor is it generally considered toxic. Since the …

Polypyridyl backbone nitrosyl complexes of ruthenium with the molecular framework [RuII
(antpy)(bpy) NO+/˙] n+ [4](PF6) 3 (n= 3),[4](PF6) 2 (n= 2), where antpy= 4′-(anthracene-9 …

Chagas disease, caused by the kinetoplastid protozoan parasite Trypanosoma cruzi,
remains a relevant cause of illness and premature death and it is estimated that 6 million to …

Trypanosomatid parasites are responsible for many Neglected Tropical Diseases (NTDs).
NTDs are a group of illnesses that prevail in low-income populations, such as in tropical and …

Introduction: There is a great interest in Nitric oxide (NO) within medicinal chemistry since it's
involved in human signaling pathways. Prodrugs or hybrid compounds containing NO-donor …

Despite ongoing efforts, the available treatments for Chagas' disease are still unsatisfactory,
especially in the chronic phase of the disease. Our previous study reported the strong …

Nitric oxide (NO) acts in different physiological processes, such as blood pressure control,
antiparasitic activities, neurotransmission, and antitumor action. Among the exogenous NO …

Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …