Few diseases have been affected more by the advent of antimicrobial therapy than bacterial
meningitis. From its recognition in 1805 to the early 20th century, bacterial meningitis was …

Bacterial meningitis remains a disease with associated unacceptable morbidity and mortality
rates despite the availability of effective bactericidal antimicrobial therapy. Through the use …

To evaluate the spectrum and regulation of matrix metalloproteinases (MMPs) in bacterial
meningitis (BM), concentrations of MMP-2, MMP-3, MMP-8, and MMP-9 and endogenous …

Postmeningitic hearing impairment is an important public health problem with implications
for both paediatric and audiology services. A recent population study has shown that, by the …

Fig. I. Proposed terminology of the septic process (systemic inflammatory response
syndrome) in children. In general, the risk of dying increases as one moves down the …

Background. Despite favorable meta-analyses, no study involving third-generation
cephalosporins for the treatment of childhood bacterial meningitis has documented a benefit …

Despite early and adequate antibiotic treatment, bacterial meningitis is an infection with a
high mortality rate, particularly for very young and elderly patients. Furthermore, recovery is …

Treatment of pneumococcal meningitis has become problematic because of the emergence
of penicillin-and cephalosporin-resistant strains and because of the concern that …

Considerable mortality is associated with gram-negative infections, especially when they are
complicated by shock (45). Although appropriate antibiotic treatment significantly reduces …

Cytokines have been implicated in the pathogenesis of gram-negative bacterial meningitis.
The effects of pentoxifylline and dexamethasone on the release of tumor necrosis factor …