Endocytic dynamins self-assemble into helical scaffolds and utilize energy from GTP
hydrolysis to constrict and sever tubular membranous necks of budded endocytic …

Congenital myopathies (CMs) are a kind of non-progressive or slow-progressive muscle
diseases caused by genetic mutations, which are currently defined and categorized mainly …

Membrane tubulation coupled with fission (MTCF) is a widespread phenomenon but
mechanisms for their coordination remain unclear, partly because of the lack of assays to …

Truncation of the protein-protein interaction SH3 domain of the membrane remodeling
Bridging Integrator 1 (BIN1, Amphiphysin 2) protein leads to centronuclear myopathy. Here …

Dynamin 2 (DNM2) is a ubiquitously expressed GTPase regulating membrane trafficking
and cytoskeleton dynamics. Heterozygous dominant mutations in DNM2 cause …

Introduction Myasthenia gravis (MG) is an autoimmune disorder. Microvesicle-derived
miRNAs have been implicated in autoimmune diseases. However, the role of microvesicle …

Abstract Dynamin, a 100-kDa GTPase, is one of the most-characterized membrane fission
machineries catalyzing vesicle release from plasma membrane during endocytosis. The …

Isoform switching of cytoskeletal proteins help muscle cells to adapt various physiological
needs. However, their involvement in deciphering differentiation signals into myogenic …

Membrane tubulation coupled with fission (MTCF) is a widespread cellular phenomenon but
mechanisms for their coordination remain unclear. This is partly because of the lack of …

A host of dynamin superfamily proteins undertake diverse membrane-active processes in
cells. Classical dynamins are paradigmatic membrane fission catalysts that release vesicles …