Unravelling the synthetic and therapeutic aspects of five, six and fused heterocycles using Vilsmeier–Haack reagent
The aim of this review is to encapsulate the synthetic protocols and medicinal aspects of a
wide range of heterocyclic compounds using the Vilsmeier–Haack (VH) reagent. These …
wide range of heterocyclic compounds using the Vilsmeier–Haack (VH) reagent. These …
Cyanoacetamide derivatives as synthons in heterocyclic synthesis
This review presents a systematic and comprehensive survey of the methods of preparation
and the chemical reactivity of cyanoacetamide derivatives. These compounds are important …
and the chemical reactivity of cyanoacetamide derivatives. These compounds are important …
Design, synthesis and biological evaluation of some pyrazole derivatives as anti-inflammatory-antimicrobial agents
AA Bekhit, T Abdel-Aziem - Bioorganic & medicinal chemistry, 2004 - Elsevier
The synthesis of novel series of structurally related 1H-pyrazolyl derivatives is described. All
the newly synthesized compounds were tested for their in vivo anti-inflammatory activity by …
the newly synthesized compounds were tested for their in vivo anti-inflammatory activity by …
Synthesis and in vitro antitumor evaluation of some indeno [1, 2-c] pyrazol (in) es substituted with sulfonamide, sulfonylurea (-thiourea) pharmacophores, and some …
SAF Rostom - Bioorganic & medicinal chemistry, 2006 - Elsevier
The synthesis of a series of 3-(4-chlorophenyl)-[1, 2-c] pyrazol (in) es substituted with
benzenesulfonamide, N1, N3-disubstituted sulfonylurea, sulfonylthiourea pharmacophores …
benzenesulfonamide, N1, N3-disubstituted sulfonylurea, sulfonylthiourea pharmacophores …
Design and synthesis of some substituted 1H-pyrazolyl-thiazolo [4, 5-d] pyrimidines as anti-inflammatory–antimicrobial agents
AA Bekhit, HTY Fahmy, SAF Rostom… - European journal of …, 2003 - Elsevier
The synthesis of two novel series of structurally related 1H-pyrazolyl derivatives of thiazolo
[4, 5-d] pyrimidines is described. All the newly synthesised compounds were examined for …
[4, 5-d] pyrimidines is described. All the newly synthesised compounds were examined for …
Polysubstituted pyrazoles, part 5. Synthesis of new 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid hydrazide analogs and some derived ring systems. A …
A novel series of 1-(4-chlorophenyl)-4-hydroxy-1H-pyrazole-3-carboxylic acid hydrazide
analogs and some derived 4-substituted-1, 2, 4-triazolin-3-thiones, 2-substituted-1, 3, 4 …
analogs and some derived 4-substituted-1, 2, 4-triazolin-3-thiones, 2-substituted-1, 3, 4 …
Design, synthesis and molecular modeling of pyrazole–quinoline–pyridine hybrids as a new class of antimicrobial and anticancer agents
CB Sangani, JA Makawana, X Zhang… - European Journal of …, 2014 - Elsevier
A new series of pyrazole–quinoline–pyridine hybrids were designed based on molecular
hybridization technique and synthesized by a base-catalyzed cyclocondensation reaction …
hybridization technique and synthesized by a base-catalyzed cyclocondensation reaction …
Azole antimicrobial pharmacophore-based tetrazoles: synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents
SAF Rostom, HMA Ashour, HA Abd El Razik… - Bioorganic & Medicinal …, 2009 - Elsevier
The azole pharmacophore is still considered a viable lead structure for the synthesis of more
efficacious and broad spectrum antimicrobial agents. Potential antibacterial and antifungal …
efficacious and broad spectrum antimicrobial agents. Potential antibacterial and antifungal …
Synthesis, characterization, and antimicrobial activity of a new pyrimidine Schiff base and its Cu (II), Ni (II), Co (II), Pt (II), and Pd (II) complexes
Abstract A new Schiff base,{1-[(5-bromo-2-hydroxy-benzylidene)-amino]-4-phenyl-2-thioxo-
1, 2-dihyro-pyrimidin-5-yl}-phenyl-methanone, was synthesized from N-amino pyrimidine-2 …
1, 2-dihyro-pyrimidin-5-yl}-phenyl-methanone, was synthesized from N-amino pyrimidine-2 …
Pyridine‐derived VEGFR‐2 inhibitors: rational design, synthesis, anticancer evaluations, in silico ADMET profile, and molecular docking
NM Saleh, AAH Abdel‐Rahman, AM Omar… - Archiv der …, 2021 - Wiley Online Library
Abstract Novel pyridine‐derived compounds (5–19) were designed and synthesized, and
their anticancer activities were evaluated against HepG2 and MCF‐7 cells, targeting the …
their anticancer activities were evaluated against HepG2 and MCF‐7 cells, targeting the …