Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1)-blockade
immunotherapies have limited efficacy in the treatment of bladder cancer. Here, we show …

Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Advances in single-cell proteomics technologies have resulted in high-dimensional datasets
comprising millions of cells that are capable of answering key questions about biology and …

Myelodysplastic syndromes (MDS) are heterogeneous neoplastic disorders of
hematopoietic stem cells (HSCs). The current standard of care for patients with MDS is …

ANPELA is widely used for quantifying traditional bulk proteomic data. Recently, there is a
clear shift from bulk proteomics to the single‐cell ones (SCP), for which powerful cytometry …

Allograft rejection is common following clinical organ transplantation, but defining specific
immune subsets mediating alloimmunity has been elusive. Calcineurin inhibitor dose …

High-dimensional cytometry (HDC) is a powerful technology for studying single-cell
phenotypes in complex biological systems. Although technological developments and …

The mRNA vaccines for SARS-CoV-2 have demonstrated efficacy and immunogenicity in
the real-world setting. However, most of the research on vaccine immunogenicity has been …

Malignant ascites accompanied by peritoneal dissemination contain various factors and cell
populations as well as cancer cells; however, how the tumor microenvironment is shaped in …

Th2 cells provide effector functions in type 2 immune responses to helminths and allergens.
Despite knowledge about molecular mechanisms of Th2 cell differentiation, there is little …