Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Novel targets to arrest neurodegeneration in several dementing conditions involving
misfolded protein accumulations may be found in the diverse signaling pathways of the …

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that
controls several important aspects of mammalian cell function. mTOR activity is modulated …

TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in
regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of …

A growing number of studies point to rapamycin as a pharmacological compound that is
able to provide neuroprotection in several experimental models of neurodegenerative …

The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central
controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in …

We report that rapamycin, an allosteric inhibitor of certain but not all actions of the key
cellular kinase mammalian target of rapamycin (mTOR), protects neurons from death in both …

ER stress–induced apoptosis is implicated in various pathological conditions, but the
mechanisms linking ER stress–mediated signaling to downstream apoptotic pathways …