Megakaryocytes are hematopoietic cells, which are responsible for the production of blood
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …

Establishment and maintenance of the blood system relies on self-renewing hematopoietic
stem cells (HSCs) that normally reside in small numbers in the bone marrow niche of adult …

Cell identity is governed by the complex regulation of gene expression, represented as gene-
regulatory networks. Here we use gene-regulatory networks inferred from single-cell multi …

The ability to produce stem cells by induced pluripotency (iPS reprogramming) has
rekindled an interest in earlier studies showing that transcription factors can directly convert …

Ethnopharmacological relevance Danshen, the dried rhizome of Salvia miltiorrhiza Bge., is
widely used to treat cardio-cerebrovascular diseases in China. However, its role in …

Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid
and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of …

Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

Background—Myocardial infarction leads to cardiac remodeling and development of heart
failure. Insufficient myocardial capillary density after myocardial infarction has been …

The GATA family of transcription factors plays fundamental roles in cell-fate specification.
However, it is unclear if these genes are necessary for the maintenance of cellular …

Background How different immune cell compartments contribute to a successful immune
response is central to fully understanding the mechanisms behind normal processes such …