Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Gene drive organisms (GDOs), whose genomes have been genetically engineered to
spread a desired allele through a population, have the potential to transform the way …

Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

In November of 2017, an interdisciplinary panel discussed the complexities of gene drive
applications as part of the third Sackler Colloquium on “The Science of Science …

Self-propagating gene drive technologies have a number of desirable characteristics that
warrant their development for the control of insect pest and vector populations, such as the …

Homing based gene drives (HGD) possess the potential to spread linked cargo genes into
natural populations and are poised to revolutionize population control of animals. Given that …

Scientists are rapidly developing synthetic gene drive elements intended for release into
natural populations. These are intended to control or eradicate disease vectors and pests, or …

Recent advances in research on gene drives have produced genetic constructs that could
theoretically spread a desired gene (payload) into all populations of a species, with a single …