Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies

P Sharma, P Srivastava, A Seth, PN Tripathi… - Progress in …, 2019 - Elsevier
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …

Current strategies in development of new chromone derivatives with diversified pharmacological activities: A review

NA Mohsin, M Irfan, S Hassan, U Saleem - Pharmaceutical chemistry …, 2020 - Springer
Chromone derivatives possess a spectrum of biological activities. Chromone has been
recognized as a privileged structure for new drug invention and development. Substitution …

Chromone, a privileged scaffold in drug discovery: Developments in the synthesis and bioactivity

AT Benny, SD Arikkatt, CG Vazhappilly… - Mini Reviews in …, 2022 - ingentaconnect.com
Chromones are the class of secondary metabolites that broadly occur in the plant kingdom
in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged …

Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics

H Madhav, E Jameel, M Rehan, N Hoda - RSC Medicinal Chemistry, 2022 - pubs.rsc.org
Neurodegenerative disorders, ie, Alzheimer's or Parkinson's disease, involve progressive
degeneration of the central nervous system, resulting in memory loss and cognitive …

Progress in target drug molecules for Alzheimer's disease

J Xie, R Liang, Y Wang, J Huang… - Current Topics in …, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease that 4 widespread in the
elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although …

Design, synthesis and antimicrobial activity of heteroannulated chromeno[3′,2′:5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines

FM Alshareef, SA Al-Harbi, ES Allehyani… - Synthetic …, 2024 - Taylor & Francis
The current research is directed to construct a novel category of linear annulated chromeno
[3, 2: 5, 6] pyrido [2, 3-d][,] thiazolo [3, 2-a] pyrimidines. The chemical reactivity of the recently …

Synthesis, biological evaluation, molecular docking, and MD simulation of novel 2, 4-disubstituted quinazoline derivatives as selective butyrylcholinesterase inhibitors …

S Sadeghian, R Razmi, S Khabnadideh… - Scientific Reports, 2024 - nature.com
Alzheimer's disease is the most prevalent neurodegenerative disorder characterized by
significant memory loss and cognitive impairments. Studies have shown that the expression …

Chromone scaffolds in the treatment of Alzheimer's and Parkinson's disease: an overview

K Sharma - ChemistrySelect, 2022 - Wiley Online Library
Neurodegenerative disorders such as Alzheimer's (AD) and Parkinson's disease (PD)
usually starts gradually and progressively worsens, and are recognized as one of the …

Efficient synthesis of chromeno [2, 3-b] pyridine derivatives using Zn (OTf) 2 as a catalyst: DFT computations, molecular docking and ADME studies

G Serdaroğlu, N Uludag, E Üstün - Journal of Molecular Liquids, 2023 - Elsevier
An efficient method was developed for the synthesis of chromeno [2, 3-b] pyridine
derivatives by using Zn (OTf) 2 (Zinc trifluoromethanesulfonate) via one-pot [3+ 3] cascade …

First Synthesis of the Novel Triazolo[3,4-b][1,3,4]Thiadiazoles and Triazolo[3,4-b][1,3,4]Thiadiazines Linked Chromeno[2,3-b]Pyridine

MA Ibrahim, SA Al-Harbi, ES Allehyani… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Abstract The novel 3-(4-amino-5-thioxo-4, 5-dihydro-1 H-1, 2, 4-triazol-3-yl)-2 H-chromeno
[2, 3-b] pyridine-2, 5 (1 H)-dione (3) was efficiently synthesized from reaction of ethyl 2, 5 …