Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Current strategies in development of new chromone derivatives with diversified pharmacological activities: A review
NA Mohsin, M Irfan, S Hassan, U Saleem - Pharmaceutical chemistry …, 2020 - Springer
Chromone derivatives possess a spectrum of biological activities. Chromone has been
recognized as a privileged structure for new drug invention and development. Substitution …
recognized as a privileged structure for new drug invention and development. Substitution …
Chromone, a privileged scaffold in drug discovery: Developments in the synthesis and bioactivity
AT Benny, SD Arikkatt, CG Vazhappilly… - Mini Reviews in …, 2022 - ingentaconnect.com
Chromones are the class of secondary metabolites that broadly occur in the plant kingdom
in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged …
in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged …
Recent advancements in chromone as a privileged scaffold towards the development of small molecules for neurodegenerative therapeutics
Neurodegenerative disorders, ie, Alzheimer's or Parkinson's disease, involve progressive
degeneration of the central nervous system, resulting in memory loss and cognitive …
degeneration of the central nervous system, resulting in memory loss and cognitive …
Progress in target drug molecules for Alzheimer's disease
J Xie, R Liang, Y Wang, J Huang… - Current Topics in …, 2020 - ingentaconnect.com
Alzheimer's disease (AD) is a chronic neurodegenerative disease that 4 widespread in the
elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although …
elderly. The etiology of AD is complicated, and its pathogenesis is still unclear. Although …
Design, synthesis and antimicrobial activity of heteroannulated chromeno[3′,2′:5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines
FM Alshareef, SA Al-Harbi, ES Allehyani… - Synthetic …, 2024 - Taylor & Francis
The current research is directed to construct a novel category of linear annulated chromeno
[3, 2: 5, 6] pyrido [2, 3-d][,] thiazolo [3, 2-a] pyrimidines. The chemical reactivity of the recently …
[3, 2: 5, 6] pyrido [2, 3-d][,] thiazolo [3, 2-a] pyrimidines. The chemical reactivity of the recently …
Synthesis, biological evaluation, molecular docking, and MD simulation of novel 2, 4-disubstituted quinazoline derivatives as selective butyrylcholinesterase inhibitors …
S Sadeghian, R Razmi, S Khabnadideh… - Scientific Reports, 2024 - nature.com
Alzheimer's disease is the most prevalent neurodegenerative disorder characterized by
significant memory loss and cognitive impairments. Studies have shown that the expression …
significant memory loss and cognitive impairments. Studies have shown that the expression …
Chromone scaffolds in the treatment of Alzheimer's and Parkinson's disease: an overview
K Sharma - ChemistrySelect, 2022 - Wiley Online Library
Neurodegenerative disorders such as Alzheimer's (AD) and Parkinson's disease (PD)
usually starts gradually and progressively worsens, and are recognized as one of the …
usually starts gradually and progressively worsens, and are recognized as one of the …
Efficient synthesis of chromeno [2, 3-b] pyridine derivatives using Zn (OTf) 2 as a catalyst: DFT computations, molecular docking and ADME studies
An efficient method was developed for the synthesis of chromeno [2, 3-b] pyridine
derivatives by using Zn (OTf) 2 (Zinc trifluoromethanesulfonate) via one-pot [3+ 3] cascade …
derivatives by using Zn (OTf) 2 (Zinc trifluoromethanesulfonate) via one-pot [3+ 3] cascade …
First Synthesis of the Novel Triazolo[3,4-b][1,3,4]Thiadiazoles and Triazolo[3,4-b][1,3,4]Thiadiazines Linked Chromeno[2,3-b]Pyridine
MA Ibrahim, SA Al-Harbi, ES Allehyani… - Polycyclic Aromatic …, 2024 - Taylor & Francis
Abstract The novel 3-(4-amino-5-thioxo-4, 5-dihydro-1 H-1, 2, 4-triazol-3-yl)-2 H-chromeno
[2, 3-b] pyridine-2, 5 (1 H)-dione (3) was efficiently synthesized from reaction of ethyl 2, 5 …
[2, 3-b] pyridine-2, 5 (1 H)-dione (3) was efficiently synthesized from reaction of ethyl 2, 5 …