The field of regenerative medicine holds considerable promise for treating diseases that are
currently intractable. Although many researchers are adopting the strategy of cell …

The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol
management and cardiovascular health. Thirty years of research have uncovered supportive …

CellProfiler has enabled the scientific research community to create flexible, modular image
analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new …

In morphological profiling, quantitative data are extracted from microscopy images of cells to
identify biologically relevant similarities and differences among samples based on these …

Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal
properties and the capacity to seed tumours. CSCs are typically refractory to conventional …

Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We
used the bioinformatics tools' expanding ploidy and allele frequency on nested …

Drug sensitivity and resistance testing on diagnostic leukemia samples should provide
important functional information to guide actionable target and biomarker discovery. We …

Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon
serial transplantation in animal models, and elimination of this cell population is required for …

Acute myeloid leukaemia (AML) is distinguished by the generation of dysfunctional
leukaemic blasts, and patients characteristically suffer from fatal infections and anaemia due …

Autophagy is a lysosomal pathway involved in degradation of intracellular material. It
appears as an adaptation mechanism that is essential for cellular homeostasis in response …