Tachykinins and tachykinin receptors: a growing family

JN Pennefather, A Lecci, ML Candenas, E Patak… - Life sciences, 2004 - Elsevier
The peptides of the tachykinin family are widely distributed within the mammalian peripheral
and central nervous systems and play a well-recognized role as excitatory …

Tachykinins and tachykinin receptors: structure and activity relationships

TA Almeida, J Rojo, PM Nieto, FM Pinto… - Current medicinal …, 2004 - ingentaconnect.com
In addition to the classical neurotransmitters, acetylcholine and noradrenaline, a wide
number of peptides with neurotransmitter activity have been identified in the past few years …

Evolutionary Rate Covariation Identifies New Members of a Protein Network Required for Drosophila melanogaster Female Post-Mating Responses

GD Findlay, JL Sitnik, W Wang, CF Aquadro… - PLoS …, 2014 - journals.plos.org
Seminal fluid proteins transferred from males to females during copulation are required for
full fertility and can exert dramatic effects on female physiology and behavior. In Drosophila …

[HTML][HTML] Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract

AC Roman, FM Pinto, I Dorta, TA Almeida… - Fertility and sterility, 2012 - Elsevier
OBJECTIVE: To investigate the presence of neurokinin B (NKB)/NK3 receptor (NK3R) and
kisspeptin/KISS1 receptor (KISS1R) messenger RNA (mRNA) and proteins throughout the …

Overview of the primary structure, tissue-distribution, and functions of tachykinins and their receptors

H Satake, T Kawada - Current drug targets, 2006 - ingentaconnect.com
Tachykinins (TKs) constitute the largest vertebrate brain/gut peptide family. Since discovery
of Substance P as a structurally unidentified vasodilatory and contractile compound in 1931 …

Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men

JJ Yang, CS Caligioni, YM Chan, SB Seminara - Endocrinology, 2012 - academic.oup.com
Patients bearing mutations in TAC3 and TACR3 (which encode neurokinin B and its
receptor, respectively) have sexual infantilism and infertility due to GnRH deficiency. In …

Tachykinins and their receptors in human malignancies

C Palma - Current Drug Targets, 2006 - ingentaconnect.com
The possibility of links between phsychosocial factors and cancer incidence and
progression has generated considerable scientific and public interest. Tachykinins …

Increased Neurokinin B (Tac2) Expression in the Mouse Arcuate Nucleus Is an Early Marker of Pubertal Onset with Differential Sensitivity to Sex Steroid-Negative Feedback than …

JC Gill, VM Navarro, C Kwong, SD Noel… - …, 2012 - academic.oup.com
At puberty, neurokinin B (NKB) and kisspeptin (Kiss1) may help to amplify GnRH secretion,
but their precise roles remain ambiguous. We tested the hypothesis that NKB and Kiss1 are …

Augmentation of metastin/kisspeptin mRNA expression by the proestrous luteinizing hormone surge in granulosa cells of rats: implications for luteinization

T Laoharatchatathanin, R Terashima… - Biology of …, 2015 - academic.oup.com
Variations in mRNA levels and sources of metastin/kisspeptin, neurokinin B (NKB),
dynorphin, and kisspeptin receptor GPR54 were examined in the ovaries of cycling rats …

Tachykinins and the hypothalamo–pituitary–gonadal axis: An update

M Lasaga, L Debeljuk - Peptides, 2011 - Elsevier
Tachykinins play a critical role in neuroendocrine regulation of reproduction. The best
known members of the family are substance P (SP), neurokinin A and neurokinin B …