While scientific advances have led to large-scale production and widespread distribution of
vaccines and antiviral drugs, viruses still remain a major cause of human diseases today …

Highlights•Evaluating drug efficacy, specificity and toxicity may help to develop an optimal
treatment regime for in vivo studies.•Measuring time to resolve viremia in vivo may help to …

Dengue is a major global health threat causing 390 million dengue infections and 25,000
deaths annually. The lack of efficacy of the licensed Dengvaxia vaccine and the absence of …

α, β, and θ defensins are effectors of the innate immune system with potent antibacterial,
antiviral, and antifungal activity. Defensins have direct antiviral activity in cell culture, with …

Flaviviruses are known to cause a variety of diseases in humans in different parts of the
world. There are very limited numbers of antivirals to combat flavivirus infection, and …

Dengue virus (DENV) infection is the most common mosquito-transmitted viral infection.
DENV infection can cause mild dengue fever or severe dengue hemorrhagic fever …

Dengue virus is the pathogenic principle behind several medical conditions. The most
common disease caused by this virus is dengue fever, characterized by high fever and flu …

The protease of dengue virus is a promising target for antiviral drug discovery. We here
report a new generation of peptide–hybrid inhibitors of dengue protease that incorporate N …

Respiratory viral infections have been a long-standing global burden ranging from seasonal
recurrences to the unexpected pandemics. The yearly hospitalizations from seasonal …

Innate immunity during acute infection plays a critical role in the disease severity of severe
acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and is …