Depression is one of the most debilitating psychiatric disorders affecting people of all ages
worldwide. Despite significant heterogeneity between studies, increased inflammation and …

Metformin is an oral hypoglycemic agent which is most widely used as first-line therapy for
type 2 diabetes. Metformin improves hyperglycemia by suppressing hepatic glucose …

Poly (ADP-ribose) polymerases (PARPs) are DNA-dependent nuclear enzymes that transfer
negatively charged ADP-ribose moieties from cellular nicotinamide-adenine-dinucleotide …

Abstract Poly (ADP-ribosyl) ation (PARylation) is a reversible protein modification carried out
by the concerted actions of poly (ADP-ribose) polymerase (PARP) enzymes and poly (ADP …

Abstract Poly (ADP-ribosyl) ation (PARylation) is a posttranslational protein modification
(PTM) catalyzed by members of the poly (ADP-ribose) polymerase (PARP) enzyme family …

Background Red wine polyphenols can prevent cardiovascular and inflammatory diseases.
Resveratrol, the most extensively studied constituent, is unlikely to solely account for these …

Despite great advances in therapies observed during the last decades, heart failure (HF)
remained a major health problem in western countries. In order to further improve symptoms …

Oxidative stress induces DNA breaks and PARP-1 activation which initiates mitochondrial
reactive oxygen species (ROS) production and cell death through pathways not yet …

Signaling cascades provide integrative and interactive frameworks that allow the cell to
respond to signals from its environment and/or from within the cell itself. The dynamic …

Aim Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, which is
characterized by massive pain and destruction of synovial joints, leads to bone erosion …