Development and therapeutic potential of DNA-dependent protein kinase inhibitors
Z Hui, H Deng, X Zhang, C Garrido, F Lirussi, XY Ye… - Bioorganic …, 2024 - Elsevier
The deployment of DNA damage response (DDR) combats various forms of DNA damage,
ensuring genomic stability. Cancer cells' propensity for genomic instability offers therapeutic …
ensuring genomic stability. Cancer cells' propensity for genomic instability offers therapeutic …
Phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring
M Andrs, J Korabecny, D Jun, Z Hodny… - Journal of medicinal …, 2015 - ACS Publications
Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein
kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell …
kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell …
Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8-and 6-aryl-substituted-1-3-benzoxazines
R Morrison, JMA Al-Rawi, IG Jennings… - European journal of …, 2016 - Elsevier
Abstract The synthesis of 6-aryl, 8-aryl, and 8-aryl-6-chloro-2-morpholino-1, 3-benzoxazines
with potent activity against PI3K and DNA-PK is described. Synthesis of thirty one analogues …
with potent activity against PI3K and DNA-PK is described. Synthesis of thirty one analogues …
Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1, 3-benzoxazines and DNA-PK and PI3K inhibition …
SK Ihmaid, JMA Al-Rawi, CJ Bradley… - European journal of …, 2012 - Elsevier
A number of new 2-(pyridin-3-ylamino)-4H-(substituted) benz [e]-1, 3-oxazin-4-ones were
synthesized 10a–g. These were then reacted with the hydro-halogen salt of 2, 3 and 4-(halo …
synthesized 10a–g. These were then reacted with the hydro-halogen salt of 2, 3 and 4-(halo …
Design, synthesis, docking studies and biological screening of 2-thiazolyl substituted-2, 3-dihydro-1H-naphtho [1, 2-e][1, 3] oxazines as potent HIV-1 reverse …
oxazine nucleus and thiazolyl group features prominently in many biologically important
natural products as well as bioactive molecules. A series of novel 2-thiazolyl substituted-2, 3 …
natural products as well as bioactive molecules. A series of novel 2-thiazolyl substituted-2, 3 …
Synthesis, in vitro antiplatelet activity and molecular modelling studies of 10-substituted 2-(1-piperazinyl) pyrimido [1, 2-a] benzimidazol-4 (10H)-ones
M Di Braccio, G Grossi, MG Signorello… - European journal of …, 2013 - Elsevier
The multistep preparation of the new 10-substituted 2-(1-piperazinyl) pyrimido [1, 2-a]
benzimidazol-4 (10H)-ones 6a–o, and of the two isomers 10-ethyl-2-(diethylamino) pyrimido …
benzimidazol-4 (10H)-ones 6a–o, and of the two isomers 10-ethyl-2-(diethylamino) pyrimido …
Polycyclic N‐Heterocyclic Compounds. Part 86: Synthesis and Evaluation of Antiplatelet Aggregation Activity of 2, 4‐Disubstituted 9‐Chloro‐5, 6‐dihydropyrimido [5, 4 …
K Okuda, S Takarada, T Hirota… - Journal of Heterocyclic …, 2015 - Wiley Online Library
Libraries of tricyclic 2‐substituted 4‐alkylamino‐9‐chloro‐5, 6‐dihydropyrimido [5, 4‐d]
benzazepines and tetracyclic 12‐substituted 8‐chloro‐1, 2, 5, 6‐tetrahydro‐4H‐imidazo …
benzazepines and tetracyclic 12‐substituted 8‐chloro‐1, 2, 5, 6‐tetrahydro‐4H‐imidazo …
A Facile Synthesis of 4-Tetrazolyl-Substituted 4H-3, 1-Benzoxazines through Sequential Passerini-Azide/Acylation/Catalytic Aza-Wittig Reaction
ZL Ren, JC Liu, MW Ding - Synthesis, 2017 - thieme-connect.com
A facile synthesis of 4-tetrazolyl-4H-3, 1-benzoxazines by a Passerini-azide/acylation/
catalytic aza-Wittig sequence was developed. The Passerini-azide reactions of 2 …
catalytic aza-Wittig sequence was developed. The Passerini-azide reactions of 2 …
Synthesis, structural elucidation, DNA-PK inhibition, homology modelling and anti-platelet activity of morpholino-substituted-1, 3-naphth-oxazines
A number of new angular 2-morpholino-(substituted)-naphth-1, 3-oxazines (compound 10b),
linear 2-morpholino-(substituted)-naphth-1, 3-oxazines (compounds 13b–c), linear 6, 7 and …
linear 2-morpholino-(substituted)-naphth-1, 3-oxazines (compounds 13b–c), linear 6, 7 and …
Non‐peptide‐based new class of platelet aggregation inhibitors: Design, synthesis, bioevaluation, SAR, and in silico studies
Abstract A series of 2‐oxo‐2‐phenylethylidene linked 2‐oxo‐benzo [1, 4] oxazine
analogues 17a–x and 18a–o, incorporated with a variety of electron‐withdrawing as well as …
analogues 17a–x and 18a–o, incorporated with a variety of electron‐withdrawing as well as …