Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor
activity, which has shown significant efficacy in pre‐clinical and clinical studies. Curcumin …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

Nuclear factor erythroid 2 p45-related factor (2Nrf2) is an essential leucine zipper protein
(bZIP) that is primarily located in the cytoplasm under physiological conditions. Nrf2 …

Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

Doxorubicin (DOX) is a well-known chemotherapeutic agent extensively applied in the field
of cancer therapy. However, similar to other chemotherapeutic agents such as cisplatin …

Background Acute kidney injury (AKI) is a common complication in clinical inpatients, and it
continues a high morbidity and mortality rate despite many clinical treatment measures. AKI …

Background Renal interstitial fibrosis (RIF) is one of the main features of diabetic
nephropathy (DN), but the molecular mechanisms mediating RIF in DN has yet been fully …

Cisplatin is a platinum-based chemotherapeutic that has long since been effective against a
variety of solid-cancers, substantially improving the five-year survival rates for cancer …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcription factor that
maintains the cell's redox balance state and reduces inflammation in different adverse …

Currently, chemotherapy is the main treatment for tumors, but there are still problems such
as unsatisfactory chemotherapy results, susceptibility to drug resistance, and serious …