Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …

DNA methylation is an epigenetic mark that regulates multiple processes, such as gene
expression and genome stability. Mutants and pharmacological treatments have been …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

DNA-editing enzymes perform chemical reactions on DNA nucleobases. These reactions
can change the genetic identity of the modified base or modulate gene expression. Interest …

Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the
local epigenetic landscape of an endogenous genomic site, often with the aim of …

Chromatin adopts different configurations that are regulated by reversible covalent
modifications, referred to as epigenetic marks. Epigenetic inhibitors have been approved for …

Culture expansion of primary cells evokes highly reproducible DNA methylation (DNAm)
changes. We have identified CG dinucleotides (CpGs) that become continuously hyper-or …

N-glycosylation is a frequent modification of proteins, essential for all domains of life. N-
glycan biosynthesis is a dynamic, complex, non-templated process, wherein specific …

Osteoarthritis (OA) is one of the most common degenerative joint diseases worldwide,
causing pain, disability, and decreased quality of life. The balance between regeneration …

The differentiation of oligodendrocyte precursor cells (OPCs) into myelinating
oligodendrocytes is the prerequisite for remyelination in demyelinated disorders such as …